Expression and prognostic role of STAT5a across cancer types.
Expression and prognostic role of STAT5a across cancer types.
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DOI：
10.1042/bsr20230612
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发表时间：
2023-08-31
影响因子：
4
通讯作者：
Li, Willis X.
中科院分区：
文献类型：
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作者：
Maninang, Christine;Li, Jinghong;Li, Willis X.
研究信号转导子和转录激活子5（STAT 5）在各种癌症中的作用产生了有争议的结果。为了解决这一争议，我们研究了STAT 5a在多种癌症患者中的预后作用。使用考克斯回归分析分析从公共数据库获得的肿瘤和正常组织之间的STAT 5 a转录水平的统计学差异，结果为总生存率，关注的协变量为高STAT 5 a表达。然后进行荟萃分析，总结考克斯回归分析的风险比估计值。我们发现STAT 5a在乳腺癌、肺癌和卵巢癌中显著低表达，而STAT 5a在淋巴瘤、弥漫性大B细胞淋巴瘤、胶质母细胞瘤和胶质瘤中显著过表达。STAT 5a高表达与膀胱癌的良好生存率显着相关（lnHR = −0.8689 [−1.4087，−0.3292]，P值= 0.0016），乳腺癌（lnHR =-0.7805 [-1.1394，-0.4215]，P值< 0.0001）和肺癌（lnHR =-0.3255 [-0.6427，-0.0083]，P值= 0.0443）。调整临床病理因素后，STAT 5a高表达与乳腺癌的良好生存率显著相关（lnHR =-0.6091 [-1.0810，-0.1372]，P值= 0.0114）。这些结果表明，较高的STAT 5a表达与乳腺癌的良好总生存率相关，因此可能具有保护作用，并且STAT 5a表达可能是潜在的预后生物标志物，特别是在乳腺癌中。然而，STAT 5a的预后作用取决于癌症类型。
Studies examining the role of signal transducer and activator of transcription 5 (STAT5) in various cancers have produced controversial results. To address this controversy, we examined the prognostic role of STAT5a in cancer patients across multiple cancers. Transcription levels of STAT5a between tumors and normal tissues, obtained from public databases, were analyzed for statistical differences using Cox regression analysis with the outcome as overall survival and covariate of interest as high STAT5a expression. Meta-analysis was then conducted to summarize the hazard ratio estimate from the Cox regression analyses. We found that STAT5a was significantly under-expressed in breast, lung, and ovarian cancers, while STAT5a was significantly overexpressed in lymphoid neoplasm diffuse large B-cell lymphoma, glioblastoma, and glioma. High STAT5a expression was significantly associated with favorable survival in bladder cancer (lnHR = −0.8689 [−1.4087, −0.3292], P-value = 0.0016), breast cancer (lnHR = −0.7805 [−1.1394, −0.4215], P-value < 0.0001) and lung cancer (lnHR = −0.3255 [−0.6427, −0.0083], P-value = 0.0443). After adjusting for clinicopathological factors, high STAT5a expression remained significantly associated with favorable survival in breast cancer (lnHR = −0.6091 [−1.0810, −0.1372], P-value = 0.0114). These results suggest that higher STAT5a expression is associated with favorable overall survival in breast cancer, and therefore might have protective effects, and that STAT5a expression could be a potential prognostic biomarker, especially in breast cancer. However, the prognostic role of STAT5a is dependent on cancer type.
影响因子：
13.5
作者：
Yu, Ji Hoon;Zhu, Bing-Mei;Riedlinger, Gregory;Kang, Keunsoo;Hennighausen, Lothar
通讯作者：
Hennighausen, Lothar
STAT5的损失通过增加TGF- {beta}和STAT3激活引起肝纤维化和癌症的发展。
DOI：
10.1084/jem.20080003
发表时间：
2009-04-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hosui A;Kimura A;Yamaji D;Zhu BM;Na R;Hennighausen L
通讯作者：
Hennighausen L