Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn's disease.
Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn's disease.
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DOI：
10.3389/fnins.2022.985190
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发表时间：
2022
影响因子：
4.3
通讯作者：
Zhou, Yan
中科院分区：
文献类型：
--
作者：
Qiu, Yage;Li, Qingshang;Wu, Dongmei;Zhang, Yiming;Cheng, Jiahui;Cao, Zhijun;Zhou, Yan
关键词：
克罗恩病 (CD) 是一种慢性复发性炎症性肠病，已被证明会产生神经系统损伤，这有可能以潜在的神经系统方式表明疾病活动。本研究的目的是调查 CD 患者脑微结构和相应功能连接（FC）的异常及其与疾病状况的关系。 22 名 CD 患者和 22 名年龄、性别和教育程度相匹配的健康对照 (HC) 参加了这项研究。所有受试者均接受平均表观传播 (MAP)-MRI 和静息态功能磁共振成像 (MRI) (rs-fMRI) 数据收集。对每位患者的病情和疾病持续时间进行临床评估。提取 MAP 指标并在两组之间进行比较。进行 Pearson 相关分析以确定 CD 组疾病特征与显着异常 MAP 指标之间的关系。用于 ROI-wise FC 分析的感兴趣区域 (ROI) 是根据其与 MAP 指标的相关性来选择的。结果显示，包括海马旁回和丘脑在内的多个大脑区域在 CD 患者和 HC 之间的 MAP 指标表现出统计学上的显着差异。此外，CD患者的左侧海马旁回和双侧丘脑以及右侧海马旁回和双侧丘脑之间的FC降低。这项工作的结果提供了初步证据，表明海马旁回（PHG）和丘脑的结构异常以及它们之间的 FC 降低可能反映了疾病的炎症程度，并可作为评估 CD 活性的大脑生物标志物。
Crohn’s disease (CD) is a chronic and relapsing inflammatory bowel disorder that has been shown to generate neurological impairments, which has the potential to signify disease activity in an underlying neurological manner. The objective of this study was to investigate the abnormalities of brain microstructure and the corresponding functional connectivity (FC) in patients with CD, as well as their associations with disease condition. Twenty-two patients with CD and 22 age-, gender-, and education-matched healthy controls (HCs) were enrolled in this study. All subjects underwent mean apparent propagator (MAP)-MRI and resting-state functional magnetic resonance imaging (MRI) (rs-fMRI) data collection. Each patient was evaluated clinically for the condition and duration of the disease. The MAP metrics were extracted and compared between two groups. Pearson’s correlation analysis was conducted to determine the relationship between disease characteristics and significantly abnormal MAP metrics in the CD group. Regions of interest (ROIs) for ROI-wise FC analysis were selected based on their correlation with MAP metrics. Results showed that multiple brain regions, including the parahippocampus and thalamus, exhibited statistically significant differences in MAP metrics between CD patients and HCs. Additionally, CD patients exhibited decreased FC between the left parahippocampus and bilateral thalamus, as well as the right parahippocampus and bilateral thalamus. The findings of this work provide preliminary evidence that structural abnormalities in the parahippocampal gyrus (PHG) and thalamus, as well as decreased FC between them, may reflect the degree of inflammatory of the disease and serve as brain biomarkers for evaluating CD activity.
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影响因子：
5.7
作者：
Avram AV;Sarlls JE;Barnett AS;Özarslan E;Thomas C;Irfanoglu MO;Hutchinson E;Pierpaoli C;Basser PJ
通讯作者：
Basser PJ
影响因子：
5.7
作者：
Fick, Rutger H. J.;Wassermann, Demian;Deriche, Rachid
通讯作者：
Deriche, Rachid
DOI：
10.1016/j.nicl.2018.09.008
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Lv K;Song W;Tang R;Pan Z;Zhang Y;Xu Y;Lv B;Fan Y;Xu M
通讯作者：
Xu M
影响因子：
5.7
作者：
Hosseinbor, A. Pasha;Chung, Moo K.;Wu, Yu-Chien;Alexander, Andrew L.
通讯作者：
Alexander, Andrew L.
影响因子：
4.3
作者：
Chen, Qi;Wang, Yao;Zhai, Guangtao
通讯作者：
Zhai, Guangtao