Coexpression of CD40 and class II antigen HLA-DR in Graves' disease thyroid epithelial cells
Coexpression of CD40 and class II antigen HLA-DR in Graves' disease thyroid epithelial cells
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DOI：
10.1006/clin.1997.4391
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发表时间：
1997-08-01
期刊：
影响因子：
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通讯作者：
Leclere, J
中科院分区：
文献类型：
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作者：
Faure, GC;BensoussanLejzerowicz, D;Leclere, J
在Graves病中，甲状腺上皮细胞在淋巴细胞浸润附近异常表达HLA-DR II类分子，表明淋巴细胞增殖是由抗原物质的适当呈递维持的。然而，甲状腺上皮细胞提供必要的第二信号的能力还没有记录。检测了30例患者甲状腺组织中HLA-DR、CD 40、CD 40 L、CD 80和CD 28的表达。用TUNEL法检测凋亡细胞。在Graves病患者样本和两个同样含有淋巴浸润的对照样本中，CD 40似乎与HLA-DR共表达。这些结果提示Graves病患者甲状腺上皮细胞具有成功提呈自身抗原的能力。周围淋巴浸润中几乎不存在凋亡细胞，这与有效提供第二个拯救信号一致。(C)北京：科学出版社.
In Graves' disease, thyroid epithelial cells abnormally express HLA-DR Class II molecules in the vicinity of lymphocyte infiltrates, suggesting that lymphocyte proliferation is sustained by the appropriate presentation of antigenic material. The ability of thyroid epithelial cells to provide the necessary second signals has however not been documented. The expression of HLA-DR, CD40, CD40L, CD80, and CD28 was investigated on thyroid samples from 30 patients (Graves' disease, n = 16; benign toxic adenoma, n = 8; multinodular goiter, n = 6). Apoptotic cells were searched for using the TUNEL method. CD40 appeared to be coexpressed with HLA-DR in Graves' disease patients samples and in two control samples also containing lymphoid infiltrates. Almost no apoptotic cells were found. These data suggest that thyroid epithelial cells from Graves' disease patients have the ability to success fully present autoantigens. The near absence of apoptotic cells in surrounding lymphoid infiltrates is in keeping with this efficient provision of a rescue second signal. (C) 1997 Academic Press.