Response of immune and susceptible ewes to infection with Toxoplasma gondii
Response of immune and susceptible ewes to infection with Toxoplasma gondii
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免疫母羊和易感母羊对弓形虫感染的反应
DOI：
10.1136/vr.111.9.175
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
D. Buxton
中科院分区：
文献类型：
--
作者：
D. Blewett;J. Miller;D. Buxton
采用含75、250或1000个刚地弓形虫组织囊的接种剂分别感染血清阴性的母羊和血清阳性的妊娠第4个月母羊。血清阴性的gimmers在所有剂量水平下均出现典型的弓形虫感染。其中四只流产，存活下来的羊羔在出生后的头两到三个月里间接血凝血浓度上升，表明先天感染。血清阳性母羊对攻击无反应，全部存活，无先天性感染的血清学证据。在整个实验过程中，血清阳性母羊的间接血凝滴度保持不变，从感染后第10天开始，母羊的间接血凝滴度急剧上升，到3个月时与母羊的间接血凝滴度相同。
Inocula containing 75, 250 or 1000 Toxoplasma gondii tissue cysts were used to infect seronegative gimmers and seropositive ewes in the fourth month of pregnancy. The seronegative gimmers developed typical toxoplasma infections at all dose levels. Four of them aborted and the surviving lambs showed rising indirect haemagglutination titres in the first two to three months of life indicating congenital infection. The seropositive ewes showed no response to challenge, all their lambs survived and there was no serological evidence of congenital infection. Indirect haemagglutination titres in the seropositive ewes remained unchanged throughout the experiment, titres in the gimmers rose sharply from the 10th day after infection and by three months were the same as those in the ewes.