In situ identification of hepatitis C virus RNA in muscle
In situ identification of hepatitis C virus RNA in muscle
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DOI：
10.1212/01.wnl.0000154605.02737.fe
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发表时间：
2005-03-22
期刊：
影响因子：
9.9
通讯作者：
Kusaka, H
中科院分区：
文献类型：
--
作者：
Ito, H;Ito, H;Kusaka, H
作者检查了4例肌炎和丙型肝炎病毒（HCV）感染患者的骨骼肌标本。PCR分析在两例患者的肌肉匀浆中鉴定出HCV RNA。在同一患者的肌纤维和浸润淋巴细胞中检测到HCV RNA的原位杂交信号。该结果可能与HCV感染患者肌炎的病理机制有关。
The authors examined skeletal muscle specimens from four patients with myositis and hepatitis C virus (HCV) infection. PCR analysis identified HCV RNA in muscle homogenates from two patients. In situ hybridization signals for HCV RNA were detected within muscle fibers as well as in infiltrating lymphocytes from the same patients. The results may relate to the pathomechanism of myositis in patients with HCV infection.