Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections
Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections
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DOI：
10.1128/jvi.78.5.2632-2636.2004
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发表时间：
2004-03-01
影响因子：
5.4
通讯作者：
Däubener, W
中科院分区：
文献类型：
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作者：
Adams, O;Besken, K;Däubener, W
γ干扰素（ifn - γ）介导的吲哚胺-2,3-双加氧酶（IDO）活性在人类星形细胞瘤细胞和天然星形细胞中被发现是抑制单纯疱疹病毒复制的原因。这种效果在过量的l -色氨酸存在下就会消失。ifn - α和ifn - β在两种细胞类型中都限制了单纯疱疹病毒的复制，但是（与ifn - γ的结果相反）添加过量的l -色氨酸并没有抑制诱导的抗病毒作用。
Gamma interferon (IFN-gamma)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts Of L-tryptophan. Both IFN-alpha and IFN-beta restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-gamma) the addition of an excess amount Of L-tryptophan did not inhibit the induced antiviral effect.