Dihydroartemisinin: A Potential Drug for the Treatment of Malignancies and Inflammatory Diseases.
Dihydroartemisinin: A Potential Drug for the Treatment of Malignancies and Inflammatory Diseases.
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DOI：
10.3389/fonc.2021.722331
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发表时间：
2021
影响因子：
4.7
通讯作者：
Fujimoto M
中科院分区：
文献类型：
--
作者：
Yu R;Jin G;Fujimoto M
几十年来，双氢青蒿素(DHA)因其在疟疾临床治疗中的有效性和安全性而被全球公认。近年来，人们发现DHA除了抗疟疾外，还具有抑制恶性肿瘤生长、调节免疫系统功能等作用。在寄生虫和肿瘤中，DHA通过诱导过量的活性氧产生而导致严重的氧化应激。DHA还通过诱导细胞程序性死亡、阻断细胞周期和增强抗肿瘤免疫来杀死肿瘤细胞。此外，DHA还通过减少炎症细胞的渗透和抑制促炎细胞因子的产生来抑制炎症。此外，基因组学、蛋白质组学、代谢组学和DHA治疗的网络药理学为阐明DHA的药理作用提供了基础。本文就DHA在抗肿瘤、抑制炎症性疾病及相关药理机制等方面的研究进展作一综述。随着DHA研究的深入，DHA有可能成为临床治疗恶性肿瘤和炎症性疾病的一种替代疗法。
Dihydroartemisinin (DHA) has been globally recognized for its efficacy and safety in the clinical treatment of malaria for decades. Recently, it has been found that DHA inhibits malignant tumor growth and regulates immune system function in addition to anti-malaria. In parasites and tumors, DHA causes severe oxidative stress by inducing excessive reactive oxygen species production. DHA also kills tumor cells by inducing programmed cell death, blocking cell cycle and enhancing anti-tumor immunity. In addition, DHA inhibits inflammation by reducing the inflammatory cells infiltration and suppressing the production of pro-inflammatory cytokines. Further, genomics, proteomics, metabolomics and network pharmacology of DHA therapy provide the basis for elucidating the pharmacological effects of DHA. This review provides a summary of the recent research progress of DHA in anti-tumor, inhibition of inflammatory diseases and the relevant pharmacological mechanisms. With further research of DHA, it is likely that DHA will become an alternative therapy in the clinical treatment of malignant tumors and inflammatory diseases.
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