Iron stores in alcohol abusers. I. Liver iron.
Iron stores in alcohol abusers. I. Liver iron.
复制标题
酗酒者体内的铁储藏室。
作者：
O. Lundvall;A. Weinfeld;P. Lundin
.储存铁已被检查，从41个酒精滥用者获得的肝活检标本，没有肝硬化和20个血液学正常的男性胆囊疾病谁是健康的。没有人有出血或铁药物治疗史。仅对男性受试者进行了检查。酗酒者主要饮用蒸馏酒。在实质细胞和枯否细胞中估计组织化学铁，并将其分级为0至4+。在20名对照者中有15名（75%）和41名酒精滥用者中有25名（61%）的实质细胞中存在1+级或以上的高铁。在库普弗细胞中，三名对照者（15%）和15名酗酒者（37%）中存在铁。两个酒精滥用者的Kupffer细胞中有铁，但在实质细胞中没有。因此，在41名酗酒者中有27名（67%）存在实质细胞或枯否细胞中1+级或以上的铁。
在37个酗酒者和20个对照组的非氯化血红素铁在肝脏中进行了化学测定。酒精滥用者的非氯化血红素铁浓度（68.3±5.8 mg/100 g干重）显著低于对照组（104.4±11.2 mg/100 g干重）。以蛋白质为参照，酒精滥用者肝脏铁含量（148.4±11.5 mg/100 g蛋白质）低于对照组（185.7±20.6 mg/100 g蛋白质）。然而，差异并不显著。没有酒精有一个非氯化血红素铁浓度高于控制范围。因此，目前的研究没有显示酒精滥用者的铁储存增加。结果表明，与对照组相比，酗酒者体内的铁储备减少。
. Storage iron has been examined in aspiration liver biopsy specimens obtained from 41 alcohol abusers without cirrhosis of the liver and from 20 hematologically normal males with gall bladder disease who were otherwise healthy. No one had a history of hemorrhage or iron medication. Only male subjects were examined. The alcoholics consumed mainly distilled alcoholic beverages. Histochemical iron was estimated in parenchymal cells and in Kupffer cells and graded 0 to 4+. Stainable iron in parenchymal cells of grade 1+ or more was present in 15 of the 20 controls (75%) and in 25 of the 41 alcohol abusers (61%). In Kupffer cells stainable iron was present in three of the controls (15%) and in 15 of the alcohol abusers (37%). Two alcohol abusers had stainable iron in the Kupffer cells but not in the parenchymal cells. Thus, stainable iron of grade 1+ or more in either parenchymal cells or Kupffer cells was present in 27 of the 41 alcoholics (67%).
In 37 alcoholics and in 20 controls non-hemin iron in the liver was determined chemically. The mean non-hemin iron concentration related to dry weight was significantly lower in the alcohol abusers (68.3±5.8 mg per 100 g dry weight) as compared with the controls (104.4±11.2 mg). With protein as reference the mean iron concentration in the liver was lower in the alcohol abusers (148.4±11.5 mg/100 g protein) as compared with the controls (185.7±20.6). The difference was, however, not significant. No alcoholic had a non-hemin iron concentration above the range of the controls. Thus, the present study did not reveal increased iron stores in alcohol abusers. The results rather indicated diminished iron stores in alcohol abusers as compared with controls.