Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian Childhood Diabetes Registry
Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian Childhood Diabetes Registry
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DOI：
10.1007/s00125-013-3090-y
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发表时间：
2014-01-01
期刊：
影响因子：
8.2
通讯作者：
Joner, Geir
中科院分区：
文献类型：
--
作者：
Skrivarhaug, Torild;Stene, Lars C.;Joner, Geir
目的/假设 我们的研究旨在描述 1989-2012 年期间挪威 15 岁以下儿童 1 型糖尿病的发病率，并评估 2004-2012 年期间的区域变化。我们进一步着手评估挪威儿童糖尿病登记处 (NCDR) 确定的完整性。方法 在 NCDR 中登记 1 型糖尿病的发病病例，并使用泊松回归对发病率进行建模。 2005-2008 年的确定情况是使用捕获-再捕获方法通过挪威处方数据库 (NorPD) 的数据进行估计的，该数据库是 2004 年建立的全国性登记册，其中包括药房向个体患者开出和配发的胰岛素。人口数据来自挪威统计局。 结果 1989-2012 年观察到的发病率表明了三个不同的时间段：1989-1996 年，平均发病率为 22.6/100,000 人年（95% CI 21.4, 23.7）； 1996-2004年，平均发病率为每10万人年28.4例（95% CI 27.3, 29.6）； 2004年至2012年，每10万人年的平均发病率为32.7（95% CI 31.5，34.0）。调整年龄和性别后，19891996 年的估计每年变化为 1.8%（95% CI -0.07, 3.6；p =0.059），1996-2004 年为 3.4%（95% CI 2.2, 4.7；p < 0.0001），2004-2012 年为 0.3%（95% CI -0.9，1.6；p = 0.64）。无论男女，10-14 岁年龄段的发病率最高。观察到发病率存在显着的区域差异（p < 0.001）。 NCDR 确定的完整性估计为 91%。 结论/解释 2004 年至 2012 年间，之前观察到的 1 型糖尿病发病率增长已趋于平稳，基本保持在每 10 万人年 32.7 例。挪威境内 1 型糖尿病的发病率存在显着差异。
Aims/hypothesis Our study aimed to describe the incidence of type 1 diabetes in children below 15 years of age in Norway during the period 1989-2012 and to assess the regional variation during 2004-2012. We further set out to estimate the completeness of ascertainment in the Norwegian Childhood Diabetes Registry (NCDR).Methods Incident cases of type 1 diabetes were registered in the NCDR and incidence rates were modelled using Poisson regression. Ascertainment for 2005-2008 was estimated using capture-recapture methodology by using data from the Norwegian Prescription Database (NorPD), a nationwide register established in 2004, which included insulin prescribed and dispensed at pharmacies to individual patients. Population data were obtained from Statistics Norway.Results Observed incidence rates for 1989-2012 suggested three distinct time segments: in 1989-1996, the average incidence rate was 22.6 per 100,000 person-years (95% CI 21.4, 23.7); in 1996-2004, the average incidence rate was 28.4 per 100,000 person-years (95% CI 27.3, 29.6); and from 2004 to 2012, the average incidence rate per 100,000 person-years was 32.7 (95% CI 31.5, 34.0). After adjustment for age and sex, the estimated change per year was 1.8% for 19891996 (95% CI -0.07, 3.6; p =0.059), 3.4% for 1996-2004 (95% CI 2.2, 4.7; p < 0.0001) and 0.3% for 2004-2012 (95% CI -0.9, 1.6; p =0.64). The highest incidence was in the age group 10-14 years for both sexes. A significant regional variation in incidence was observed (p < 0.001). Completeness of ascertainment in the NCDR was estimated to be 91%.Conclusions/interpretation The previously observed increase in incidence of type 1 diabetes has levelled off and remained essentially constant at 32.7 per 100,000 person-years during 2004-2012. There is a significant variation in type 1 diabetes incidence within Norway.