How Green Is the Grass on the Other Side? Frontopolar Cortex and the Evidence in Favor of Alternative Courses of Action
How Green Is the Grass on the Other Side? Frontopolar Cortex and the Evidence in Favor of Alternative Courses of Action
复制标题
DOI：
10.1016/j.neuron.2009.05.014
复制
发表时间：
2009-06-11
期刊：
影响因子：
16.2
通讯作者：
Rushworth, Matthew F. S.
中科院分区：
文献类型：
--
作者：
Boorman, Erie D.;Behrens, Timothy E. J.;Rushworth, Matthew F. S.
行为灵活性是目标导向行为的标志。当外部环境的特征明确地提示行为调整时，我们对行为调整的神经基础了解很多，但当这种变化是在不确定的证据基础上做出时，我们对我们的行为如何适应却知之甚少。使用贝叶斯学习模型和功能磁共振成像，我们表明，额极皮层（FPC）跟踪的相对优势，有利于切换到一个既定的选择时，自愿作出的选择。当受试者最终决定切换到替代行为时，FPC功能连接发生变化。此外，FPC信号的个体间变化预测了有效适应行为的个体间差异。相比之下，腹内侧前额叶皮层（vmPFC）编码当前决策的相对价值。总的来说，这些发现揭示了对促进短期和长期行为灵活性至关重要的补充前额叶计算。
Behavioral flexibility is the hallmark of goal-directed behavior. Whereas a great deal is known about the neural substrates of behavioral adjustment when it is explicitly cued by features of the external environment, little is known about how we adapt our behavior when such changes are made on the basis of uncertain evidence. Using a Bayesian reinforcement-learning model and fMRI, we show that frontopolar cortex (FPC) tracks the relative advantage in favor of switching to a foregone alternative when choices are made voluntarily. Changes in FPC functional connectivity occur when subjects finally decide to switch to the alternative behavior. Moreover, interindividual variation in the FPC signal predicts interindividual differences in effectively adapting behavior. By contrast, ventromedial prefrontal cortex (vmPFC) encodes the relative value of the current decision. Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility.