MATERNAL ESSENTIAL FATTY-ACID PATTERNS DURING NORMAL-PREGNANCY AND THEIR RELATIONSHIP TO THE NEONATAL ESSENTIAL FATTY-ACID STATUS
MATERNAL ESSENTIAL FATTY-ACID PATTERNS DURING NORMAL-PREGNANCY AND THEIR RELATIONSHIP TO THE NEONATAL ESSENTIAL FATTY-ACID STATUS
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DOI：
10.1079/bjn19950106
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发表时间：
1995-07-01
影响因子：
3.6
通讯作者：
HORNSTRA, G
中科院分区：
文献类型：
--
作者：
AL, MDM;VANHOUWELINGEN, AC;HORNSTRA, G
虽然必需脂肪酸（EFA）和它们的长链，更不饱和的衍生物在怀孕期间发挥了重要作用，几乎没有任何信息是关于在一个简单的怀孕过程中的母亲EFA状态及其与新生儿EFA状态的关系。因此，开始了一项纵向研究，其中110名孕妇从妊娠第10周至分娩期间重复提供血液样本。出生后，还收集来自脐静脉的血液样品和母体静脉血液样品，并且在分娩后6个月，从母亲采集最终血液样品。测定了血浆磷脂中脂肪酸的含量（%总脂肪酸），妊娠期间脂肪酸的总量显著增加，亚油酸（18：2n-6）的相对量在妊娠期间没有变化，而花生四烯酸（20：4 n-6）的相对量减少，尽管母体动员了二十二碳六烯酸（二十二：6 n-3，DHA），这是由DHA状态的暂时增加直到妊娠18周所暗示的，此后DHA状态稳步下降，这种模式与整个怀孕期间母体血液中DHA缺乏指数的逐渐增加有关，并导致新生儿DHA状态不佳。在目前的饮食条件下，能够满足胎儿对EFA的高需求。
Although essential fatty acids (EFA) and their longer chain, more unsaturated derivatives play a major role during pregnancy, hardly any information is available with respect to the course of the maternal EFA status during an uncomplicated pregnancy and its relationship to the neonatal EFA status. Therefore, a longitudinal study was started in which 110 pregnant women gave repeated blood samples from the 10th week of gestation until delivery. After birth a blood sample from the umbilical vein and a maternal venous blood sample were collected as well, and 6 months after delivery a final blood sample from the mother was taken, The absolute (mg/l) and relative (% total fatty acids) amounts of the fatty acids in plasma phospholipids were determined, The total amounts of fatty acids increased significantly during pregnancy, This pattern was similar for the individual fatty acids and fatty acid families, The relative amount of linoleic acid (18:2n-6) did not change during pregnancy, whereas the relative amount of arachidonic acid (20:4n-6) decreased, Despite maternal mobilization of docosahexaenoic acid (22:6n-3, DHA), suggested by a temporary increase in the DHA status until 18 weeks gestation, the DHA status steadily declined thereafter, This pattern was associated with a progressive increase in the DHA deficiency index in maternal blood throughout pregnancy and resulted in a sub-optimal neonatal DHA status, The overall maternal EFA status also declined steadily during pregnancy, Therefore, the question arises whether the mother, under the prevailing dietary conditions, is able to meet the high fetal requirement for EFA.