Proteoglycans in normal and severely osteoarthritic human cartilage.
Proteoglycans in normal and severely osteoarthritic human cartilage.
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正常和严重骨关节炎人类软骨中的蛋白多糖。
DOI：
10.1042/bj1870781
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Vasan,N
中科院分区：
文献类型：
--
作者：
Vasan,N
将来自骨关节炎软骨的蛋白多糖与来自正常关节软骨的蛋白多糖进行比较。正常的蛋白多糖聚集体比骨关节炎中的蛋白多糖聚集体尺寸更大且更均匀。两种来源的蛋白聚糖单体在受控孔径玻璃珠色谱上给出两个峰。尽管来自正常软骨的延迟材料显示出对透明质酸盐的亲和力，但来自骨关节炎软骨的相同材料却没有。部分处于空隙体积且部分延迟的材料的透明质酸结合能力在两种类型的软骨中是相似的。这些结果表明，在骨关节炎软骨中，蛋白多糖聚集体更小且更异质，并且硫酸软骨素侧链更短。他们还表明，存在两种蛋白多糖，一种具有完整的核心蛋白透明质酸结合蛋白区域，另一种具有非活性结合区域或完全缺乏该区域。
Proteoglycans from osteoarthritic cartilage were compared with those from normal articular cartilage. Normal proteoglycan aggregates are larger in size and more homogeneous than those in osteoarthritis. Proteoglycan monomers from both sources gave two peaks on controlled pore glass-bead chromatography. Although the retarded material from normal cartilage showed an affinity for hyaluronate, the same material from osteoarthritic cartilage did not. The hyaluronate-binding capacity of the material which is partly in the void volume and partly retarded was similar in both types of cartilage. These results suggest that in osteoarthritic cartilage the proteoglycan aggregates are smaller and more heterogeneous and that the chondroitin sulphate side chains are shorter. They also indicate that there are two populations of proteoglycan, one with its hyaluronate-binding-protein region of core protein intact and the other either possessing an inactive binding region or totally lacking it.