Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial
Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial
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DOI：
10.1111/cen.12942
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发表时间：
2016-03-01
影响因子：
3.2
通讯作者：
Rejnmark, Lars
中科院分区：
文献类型：
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作者：
Amstrup, Anne Kristine;Sikjaer, Tanja;Rejnmark, Lars
目的褪黑素除了调节昼夜节律外，还在生物体内发挥多种作用。在这些功能中，褪黑素被认为对体重和能量代谢有积极作用。到目前为止，这方面的证据主要依赖于动物模型。在这项研究中，我们旨在确定褪黑素对人体成分、脂肪和葡萄糖代谢的影响。设计/方法在一项双盲、安慰剂对照研究中，我们随机选择81名绝经后妇女接受褪黑素(每晚1或3毫克)或安慰剂治疗1年。用DXA测量体成分。在基线和治疗1年后测量瘦素、脂联素和胰岛素。结果与安慰剂组相比，褪黑素组的脂肪量减少了69%(95%可信区间：14%；124%，P=002)。与安慰剂组(33%，IQR：-17；62)和-19%(IQR：-57；58)相比，褪黑素组的瘦体重增加了52%，P=008。调整BMI后，褪黑激素组瘦体重增加了26%(95%CI：01；50，P=004)。体重和BMI的变化在不同组之间没有差异。与安慰剂相比，褪黑素组的脂联素显著增加了21%的临界值(P=008)。瘦素、胰岛素和血糖稳态指标未见明显变化。结论褪黑素治疗1年可减少脂肪量，增加瘦肉量，并与脂联素升高的趋势有关，可能对身体成分和脂代谢有有益影响。
ObjectiveApart from regulating the circadian rhythm, melatonin exerts a variety of actions in the living organism. Among these functions, melatonin is believed to have a positive effect on body weight and energy metabolism. So far, the evidence for this relies mainly on animal models. In this study, we aimed to determine the effects of melatonin on body composition, lipid and glucose metabolism in humans.Design/methodsIn a double-blind, placebo-controlled study, we randomized 81 postmenopausal women to 1 year of treatment with melatonin (1 or 3 mg nightly) or placebo. Body composition was measured by DXA. Measures were obtained at baseline and after 1 year of treatment along with leptin, adiponectin and insulin. Markers of glucose homeostasis were measured at the end of the study.ResultsIn response to treatment, fat mass decreased in the melatonin group by 69% (95% CI: 14%; 124%, P = 002) compared to placebo. A borderline significant increase in lean mass of 52% was found in the melatonin group compared to placebo (33%, (IQR:-17; 62) vs -19%, (IQR: -57; 58), P = 008). After adjusting for BMI, lean mass increased by 26% (95% CI: 01; 50, P = 004) in the melatonin group. Changes in body weight and BMI did not differ between groups. Adiponectin increased borderline significantly by 21% in the melatonin group compared to placebo (P = 008). No significant changes were observed for leptin, insulin or markers of glucose homeostasis.ConclusionOur results suggest a possibly beneficial effect of melatonin on body composition and lipid metabolism as 1 year of treatment reduces fat mass, increases lean mass and is associated with a trend towards an increase in adiponectin.