Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.

Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
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慢性淋巴细胞白血病同种异体骨髓移植后的移植物抗白血病效应。

DOI:
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发表时间:
1996
影响因子:
4.8
通讯作者:
R. Champlin
R. Champlin
中科院分区:
医学3区
文献类型:
--
作者:
G. Rondon;S. Giralt;Yang O. Huh;I. Khouri;B. Andersson;Michael Andreeff;R. Champlin

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我们报告一例慢性淋巴细胞白血病患者在异基因骨髓移植后出现持续性淋巴细胞增多和淋巴结肿大。在第87天接受供体淋巴细胞输注后,他在慢性移植物抗宿主病的发展中达到完全缓解,这表明移植物抗白血病效应在这种恶性肿瘤中是有效的。
We report the case of a patient with chronic lymphocytic leukemia (CLL) with persistent lymphocytosis and lymphadenopathy after allogeneic bone marrow transplantation (BMT). After receiving a donor lymphocyte infusion on day 87 he achieved complete remission upon development of chronic graft-versus-host disease, suggesting that a graft-versus-leukemia effect is operative in this malignancy.