Telomere dynamics in Macaques and humans
Telomere dynamics in Macaques and humans
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DOI：
10.1093/gerona/62.4.367
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发表时间：
2007-04-01
影响因子：
5.1
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
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作者：
Gardner, Jeffrey P.;Kimura, Masayuki;Aviv, Abraham
在人类中，增殖组织中的端粒长度随着年龄的增长而缩短，而与年龄相关的疾病会加速这一过程。因此，非人类灵长类动物的端粒长度和随年龄的消耗可能成为理解人类端粒生物学的有用范例。我们检查了年轻和年老食蟹猴组织中的端粒参数，并将它们与人类的几种组织进行了比较。猕猴端粒的长度各不相同，并且在动物体内表现出部分同步（等效）。它们比人类长，部分原因是亚端粒片段更长。由于骨骼肌端粒长度随着年龄的增长而变化，我们用它作为内部参考来抵消动物间端粒长度的差异。我们在肺、胰腺、皮肤和甲状腺中发现了年龄依赖性端粒磨损。与人类相似，在脾脏、胸腺、消化道和性腺中也检测到了端粒酶活性。我们得出的结论是，改变人类端粒磨损和衰老的因素也可能在猕猴身上发挥作用。
In humans, telomere length in proliferating tissues shortens with age-a process accelerated with age-related diseases. Thus, telomere length and attrition with age in the nonhuman primate may serve as a useful paradigm for understanding telomere biology in humans. We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. Macaque telomeres were variable in length and exhibited partial synchrony (equivalence) within animals. They were longer than humans, partially because of longer subtelomeric segments. As skeletal muscle telomere length was unchanged with age, we used it as an internal reference to offset interanimal variation in telomere length. We identified age-dependent telomere attrition in lung, pancreas, skin, and thyroid. Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque.