Patients with breast cancer: Differences in color Doppler flow and gray-scale US features of benign and malignant axillary lymph nodes
Patients with breast cancer: Differences in color Doppler flow and gray-scale US features of benign and malignant axillary lymph nodes
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DOI：
10.1148/radiology.215.2.r00ap20568
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发表时间：
2000-05-01
期刊：
影响因子：
19.7
通讯作者：
Metreweli, C
中科院分区：
文献类型：
--
作者：
Yang, WT;Chang, J;Metreweli, C
目得：目的：探讨原发性乳腺癌患者腋窝淋巴结良恶性的彩色多普勒血流和灰阶超声（US）特征的差异。对135名女性的145个腋窝淋巴结的彩色多普勒血流和灰阶超声图像进行了前瞻性研究（69名女性74个可触及的淋巴结，66名女性71个不可触及的淋巴结）原发性乳腺癌。结内血流分布被描述为外周、中央或中央肺门周围。记录阻力指数、搏动指数和收缩期峰值流速。为了比较良性和恶性的特点，淋巴结被分为三组：可触及和不可触及，可触及，和nonpalping.Results：彩色血流显示同样好，在良性和恶性腋淋巴结的所有三组。对于所有淋巴结，恶性淋巴结（153个淋巴结中的118个[77%]）的外周血流明显高于良性淋巴结（160个淋巴结中的45个[28%]）（P <0.001）;良性淋巴结的中心血流和中心门周血流明显高于恶性淋巴结（分别为P <0.002和<0.001）。在不可触及的淋巴结中未观察到类似的差异。恶性淋巴结的平均横径-横轴比（+/- SD）（1.8 +/- 0.6）显著低于良性淋巴结（2.6 +/- 0.8）。Logistic回归分析显示，周边，中央，中央perhilar流量和平均横径横轴比是显着的独立预测malignancy.CONCLUSION：彩色多普勒血流和灰阶超声特征适用于识别乳腺癌患者的腋窝淋巴结可触及的疾病不适用于未触及的节点。
PURPOSE: To document differences in color Doppler flow and gray-scale ultrasonographic (US) features between benign and malignant axillary lymph nodes in women with primary breast cancer.MATERIALS AND METHODS: The longitudinal-transverse axis ratio and hilar status on color Doppler flow and gray-scale US images were prospectively studied for each of 145 axillary nodes in 135 women (74 palpable nodes in 69 women, 71 nonpalpable nodes in 66 women) with primary breast cancer. Intranodal flow distribution was described as peripheral, central, or central perhilar. Resistive and pulsatility indexes and peak systolic velocity were documented. For comparison of benign and malignant features, nodes were divided into three groups: palpable and nonpalpable, palpable, and nonpalpable.RESULTS: Color flow was demonstrated equally well in benign and malignant axillary lymph nodes for all three groups. For all nodes, peripheral flow was significantly higher in malignant (118 of 153 nodes [77%]) than benign (45 of 160 nodes [28%]) nodes (P < .001); central flow and central perhilar flow were significantly greater (P < .002 and < .001, respectively) in benign than malignant nodes. Similar differences were not observed in nonpalpable nodes. The mean longitudinal-transverse axis ratio (+/- SD) was significantly lower in malignant (1.8 +/- 0.6) than benign (2.6 +/- 0.8) nodes. Logistic regression analysis showed peripheral, central, and central perhilar flow and the mean longitudinal-transverse axis ratio to be significant independent predictors of malignancy.CONCLUSION: Color Doppler flow and gray-scale US features applicable to the identification of disease in palpable axillary nodes in patients with breast cancer are not applicable to nonpalpable nodes.