PRIMARY MALIGNANT NEOPLAMS OF NERVES (MALIGNANT NEURILEMOMAS) IN PATIENTS WITHOUT MANIFESTATIONS OF MULTIPLE NEUROFIBROMATOSIS (VON RECKLINGHAUSENS DISEASE)
PRIMARY MALIGNANT NEOPLAMS OF NERVES (MALIGNANT NEURILEMOMAS) IN PATIENTS WITHOUT MANIFESTATIONS OF MULTIPLE NEUROFIBROMATOSIS (VON RECKLINGHAUSENS DISEASE)
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DOI：
10.1002/1097-0142(196308)16:8
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发表时间：
1963-01-01
期刊：
影响因子：
6.2
通讯作者：
MILLER, RH
中科院分区：
文献类型：
--
作者：
DAGOSTINO, AN;SOULE, EH;MILLER, RH
本文复习了24例原发性神经恶性肿瘤的临床资料。选择这些肿瘤的依据是，在没有多发性神经纤维瘤病的情况下，这些肿瘤局限于大的、解剖学上确定的神经干。所有恶性神经鞘瘤都是高度细胞性的，主要表现为交织的束状图案，很容易找到有丝分裂的图形。唯一区别恶性神经鞘瘤和纤维肉瘤的特征是起源于神经干。网状蛋白染色无助于区分这两种实体。自上次手术治疗以来，15名被追踪的患者中有4名存活超过5年。在接受单纯或根治性局部手术治疗的19名患者中，有12名患者肿瘤复发。提示一期截肢可使患者获得最好的治愈机会。当该手术在解剖学上不可行时，应尝试根治性局部切除。
Twenty-four carefully selected cases of primary malignant tumors of nerves are reviewed. These tumors were selected on the basis of being confined to large, anatomically identified nerve trunks in the absence of multiple neurofibromatosis. All malignant neurilemomas were highly cellular and presented predominantly a pattern of interlacing bundles with easily found mitotic figures. The only feature distinguishing a malignant neurilemoma from a fibrosarcoma is origin within the nerve trunk. The reticulin stains were not helpful in differentiating these 2 entities. Four of 15 traced patients have survived more than 5 years since the last surgical treatment. Twelve of 19 patients subjected to simple or radical local form of surgical treatment have experienced a recurrence of the tumor. It is suggested that primary amputation may give the patient the best chance of cure. When this procedure is not anatomically feasible, radical local excision should be attempted.