Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient
Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient
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DOI：
10.1038/sj.bmt.1702593
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发表时间：
2000-11-01
影响因子：
4.8
通讯作者：
Neudorf, S
中科院分区：
文献类型：
--
作者：
Lones, MA;Kirov, I;Neudorf, S
移植后淋巴增生性疾病(PTLD)是异基因骨髓移植(BMT)的并发症之一。自体骨髓移植后罕见的PTLD病例仅在成人中有报道。本病例首次报道了1例儿童自体外周干细胞移植(PSCT)后PTLD的病例，这位2岁的男性IV期神经母细胞瘤患者接受了自体PSCT，PSCT后的病程伴有发热、便血和肺部肿块。在PSCT后第94天，结肠镜检查发现由于与Epstein-Barr病毒相关的PTLD，单形型，B细胞表型引起的溃疡。细针抽吸证实肺肿块为神经母细胞瘤，PTLD可发生在儿童自体PSCT受者，更多发生在T细胞耗尽或CD34(+)细胞选择的自体移植物中。
Post-transplant lymphoproliferative disorder (PTLD) is a complication of allogeneic bone marrow transplantation (BMT). Rare cases of PTLD after autologous BMT have been reported only in adults. This case report is the first to describe PTLD in a pediatric patient after autologous peripheral stem cell transplantation (PSCT), This 2-year-old male with stage IV neuroblastoma underwent autologous PSCT, The post-PSCT course was complicated by fever with hematochezia and a lung mass. On day 94 post PSCT, colonoscopy revealed an ulcer due to a PTLD, monomorphic type, B cell phenotype, associated with Epstein-Barr virus. Fine needle aspiration identified the lung mass as neuroblastoma, PTLD can occur in pediatric autologous PSCT recipients, and may occur more frequently in autologous grafts manipulated by T cell depletion or CD34(+) cell selection.