Angiotensin-(1-7) prevents atrial fibrosis and atrial fibrillation in long-term atrial tachycardia dogs
Angiotensin-(1-7) prevents atrial fibrosis and atrial fibrillation in long-term atrial tachycardia dogs
复制标题
血管紧张素-(1-7)可预防长期房性心动过速犬的心房纤维化和房颤
DOI：
10.1016/j.regpep.2009.12.020
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发表时间：
2010-06-08
影响因子：
--
通讯作者：
Li, Guangping
中科院分区：
文献类型：
--
作者：
Liu, Enzhao;Yang, Shengrong;Li, Guangping
肾素-血管紧张素系统（RAS）在心房肌中被激活。血管紧张素-（1-7）[Ang-（1 - 7）]抵消血管紧张素（Ang II）的作用。为探讨Ang-（1-7）对长期房性心动过速诱导的心房纤维化和心房颤动（AF）易损性的影响，将18只犬随机分为假手术组、起搏组和起搏+ Ang-（1-7）组，每组6只。以500 bpm的速度快速心房起搏持续14天，而假手术组中的狗不进行起搏。起搏期间静脉注射Ang-（1-7）（6 μ g.kg（-1）.h（-1））。起搏后检测心房组织ERK 1/ERK 2 mRNA表达及心房纤维化程度，观察房颤的诱发率及持续时间。与假手术组相比，起搏组ERK 1/ERK 2 mRNA表达增加（P
Renin-angiotensin system (RAS) is activated in the fibrillating atria. Angiotensin-(1-7) [Ang-(1 -7)] counterbalances the actions of angiotensin (Ang II). To investigate the effects of Ang-(1-7) on the long-term atrial tachycardia-induced atrial fibrosis and atrial fibrillation (AF) vulnerability, eighteen dogs were assigned to sham group, paced group, or paced + Ang-(1-7) group, 6 dogs in each group. Rapid atrial pacing at 500 bpm was maintained for 14 days, but dogs in the sham group were instrumented without pacing. During the pacing, Ang-( 1-7) (6 mu g.kg(-1).h(-1)) was given intravenously. After pacing, atrial mRNA expression of ERK1/ERK2 and atrial fibrosis were assessed, the inducibility and duration of AF were measured. Compared with sham, ERK1/ERK2 mRNA expression was increased in the paced group (P