PINEAL-RETINAL MOLECULAR RELATIONSHIPS - DISTRIBUTION OF S-ANTIGEN IN THE PINEAL COMPLEX
PINEAL-RETINAL MOLECULAR RELATIONSHIPS - DISTRIBUTION OF S-ANTIGEN IN THE PINEAL COMPLEX
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DOI：
10.1016/0306-4522(86)90288-5
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发表时间：
1986-10-01
期刊：
影响因子：
3.3
通讯作者：
FAURE, JP
中科院分区：
文献类型：
--
作者：
COLLIN, JP;MIRSHAHI, M;FAURE, JP
本文研究了首次在视网膜光感受器中发现的特异性蛋白S-抗原在脊椎动物松果体复合体中的免疫细胞化学定位（鳗鱼、狗鱼、青蛙、蜥蜴、雀形目、小鼠、仓鼠）使用单克隆抗体免疫荧光，在视网膜光感受器和所有物种的大多数松果体光传感器（即受体系列的松果体细胞）中同时证明了S抗原免疫反应性（视锥样、修饰的感光细胞、松果体细胞）和青蛙额器官和蜥蜴顶眼的视锥样感光细胞中。标记分布在这些细胞的所有隔室中，或仅限于外节。讨论了S抗原的功能意义以及该标记的一些系统发育和个体发育意义。
The immunocytochemical localization of S-antigen, a specific protein first discovered in retinal photoreceptors, was studied in the pineal complex of vertebrates (eel, pike, frog, lizard, passerines, mouse, hamster) using monoclonal antibody immunofluoresence, S-antigen immunoreactivity was demonstrated concurrently in retinal photoreceptors and in most pineal phototransducers of all species, i.e. in pineal cells of the receptor series (cone-like, modified photoreceptor cells, pinealocytes) and in cone-like photoreceptors of the frog frontal organ and lizard parietal eye. The labelling was distributed either in all compartments of these cells, or restricted to outer segments. The functional significance of the S-antigen as well as some phylogenetic and ontogenic implication of this marker are discussed.