Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer's Disease.
Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer's Disease.
复制标题
阿尔茨海默病中认知相关小脑亚区的功能连接发生改变。
DOI：
10.3389/fnagi.2017.00143
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发表时间：
2017
影响因子：
4.8
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zheng W;Liu X;Song H;Li K;Wang Z
阿尔茨海默病(AD)是导致痴呆症的最常见原因。先前的研究发现AD患者各种脑网络的静息功能连接性(RsFC)被破坏。然而，很少有研究集中于AD患者小脑及其亚区的rsFCs。在这项研究中，我们收集了32例AD患者和38例健康对照组的静息功能磁共振成像(rS-fMRI)数据。我们选择了两个认知相关的小脑亚区作为种子区域，并绘制了每个亚区的全脑rsFCs图。我们发现与认知相关的两个小脑亚区存在几种不同的rsFC模式：默认模式网络(DMN)、额顶网络(FPN)、视觉网络(VN)和感觉运动网络(SMN)。与对照组相比，AD患者在多个不同的网络(DMN、VN和SMN)中表现出rsFCs的破坏，预示着小脑功能整合的损害。值得注意的是，小脑两个亚区的这些异常rsFC与认知能力密切相关。总而言之，我们展示了具有不同功能网络的小脑亚区域的不同rsFCs模式，这些网络在AD患者中受到不同程度的损害。
Alzheimer’s disease (AD) is the most common cause of dementia. Previous studies have found disrupted resting state functional connectivities (rsFCs) in various brain networks in the AD patients. However, few studies have focused on the rsFCs of the cerebellum and its sub-regions in the AD patients. In this study, we collected resting-state functional magnetic resonance imaging (rs-fMRI) data including 32 AD patients and 38 healthy controls (HCs). We selected two cognitive-related subregions of the cerebellum as seed region and mapped the whole-brain rsFCs for each subregion. We identified several distinct rsFC patterns of the two cognitive-related cerebellar subregions: default-mode network (DMN), frontoparietal network (FPN), visual network (VN) and sensorimotor network (SMN). Compared with the controls, the AD patients showed disrupted rsFCs in several different networks (DMN, VN and SMN), predicting the impairment of the functional integration in the cerebellum. Notably, these abnormal rsFCs of the two cerebellar subregions were closely associated with cognitive performance. Collectively, we demonstrated the distinct rsFCs patterns of cerebellar sub-regions with various functional networks, which were differentially impaired in the AD patients.