A single intraperitoneal injection of endotoxin changes glial cells in rats as revealed by positron emission tomography using [11C]PK11195.
A single intraperitoneal injection of endotoxin changes glial cells in rats as revealed by positron emission tomography using [11C]PK11195.
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使用 [11C]PK11195 的正电子发射断层扫描显示，单次腹膜内注射内毒素会改变大鼠的神经胶质细胞。
DOI：
10.1007/s13139-017-0510-9
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kunugi H
中科院分区：
文献类型：
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作者：
Ota M;Ogura J;Ogawa S;Kato K;Matsuda H;Kunugi H
目的颅内注射脂多糖（LPS）可引起快速的先天性免疫反应，激活脑内胶质细胞，并诱导抑郁样行为。然而，没有研究集中在神经胶质细胞的变化诱导腹腔注射LPS invivo.MethodsTen成年雄性Fischer F344大鼠进行[11 C]PK11195 PET前和2天后腹腔注射LPS，以评估神经胶质细胞的变化。在标准化摄取值（SUV）的[11 C]PK11195之间的差异之前和注射后determined.ResultsThere是一个集群的大脑区域，表现出显着减少SUV。这一集群包括双侧纹状体和双侧额叶区，尤其是躯体感觉regions.ConclusionsChanges的神经胶质细胞活性的变化引起的腹腔注射LPS在体内检测的[11 C]PK11195 PET。已知腹腔注射LPS可诱导抑郁症，进一步研究[11 C]PK11195 PET将阐明神经炎症和抑郁症之间的关系。
PurposeIntracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.MethodsTen adult male Fischer F344 rats underwent [11C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [11C]PK11195 between before and after injection was determined.ResultsThere was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.ConclusionsChanges in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [11C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [11C]PK11195 PET would clarify the relationships between neuroinflammation and depression.