Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis
Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis
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DOI：
10.1016/j.bmc.2004.08.007
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发表时间：
2004-11-01
影响因子：
3.5
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Komatsu, K;Tsuda, M;Kobayashi, J
从致病放线菌巴西诺卡氏菌IFM0406的发酵液中分离得到3个新的三环萜类化合物，它们是Brasilardins B-D(2-4)和有效的免疫抑制化合物Brasilardin A(1)，其结构和立体化学经光谱分析和单晶X-射线衍射分析确定。2-4的免疫抑制和细胞毒活性与1进行了比较。(C)2004年爱思唯尔有限公司。保留所有权利。
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1. (C) 2004 Elsevier Ltd. All rights reserved.