Sex differences in stroke across the lifespan: The role of T lymphocytes.
Sex differences in stroke across the lifespan: The role of T lymphocytes.
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DOI：
10.1016/j.neuint.2017.01.009
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发表时间：
2017-07
影响因子：
4.2
通讯作者：
Liu F
中科院分区：
文献类型：
--
作者：
Bravo-Alegria J;McCullough LD;Liu F
中风是一种两性异形疾病。缺血敏感性在整个生命周期中的变化和结果在很大程度上取决于年龄，性别，激素状态，炎症和其他现有风险因素等变量。中风后的免疫反应在这些因素如何相互作用中起着核心作用。虽然中风后的免疫反应已经得到了广泛的研究，淋巴细胞在中风中的作用仍然没有得到很好的理解。T细胞在中风的急性和慢性阶段参与先天性和适应性免疫应答。T细胞的反应也会在不同的年龄发生变化，并受到激素和性染色体的调节。T细胞也与高血压的发展有关，高血压是血管疾病最重要的危险因素之一。在这篇综述中，我们强调了最近的文献中的淋巴细胞反应中风的背景下，年龄和性别，重点是T细胞反应和重要的中风危险因素的相互作用。
Stroke is a sexually dimorphic disease. Ischemic sensitivity changes throughout the lifespan and outcomes depend largely on variables like age, sex, hormonal status, inflammation, and other existing risk factors. Immune responses after stroke play a central role in how these factors interact. Although the post-stroke immune response has been extensively studied, the contribution of lymphocytes to stroke is still not well understood. T cells participate in both innate and adaptive immune responses at both acute and chronic stages of stroke. T cell responses also change at different ages and are modulated by hormones and sex chromosome compliment. T cells have also been implicated in the development of hypertension, one of the most important risk factors for vascular disease. In this review, we highlight recent literature on the lymphocytic responses to stroke in the context of age and sex, with a focus on T cell response and the interaction with important stroke risk factors.