Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects:: a preliminary proton MRS study
Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects:: a preliminary proton MRS study
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DOI：
10.1016/s0925-4927(02)00088-4
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发表时间：
2002-11-30
影响因子：
2.3
通讯作者：
Sullivan, EV
中科院分区：
文献类型：
--
作者：
Nordahl, TE;Salo, R;Sullivan, EV
基于动物模型的研究报告说，甲基苯丙胺（MA）滥用会减少大脑额叶区域的多巴胺（DA）和血清素神经支配。在这项人体体内研究中，我们使用质子磁共振波谱（MRS）来检测n -乙酰-天冬氨酸（NAA），这是一种活神经元的标记物，以检查可能受甲基苯丙胺依赖（MD）影响的额叶脑区域。我们测试了MD受试者在前扣带灰质中表现出异常低水平的NAA（指肌酸（Cr））的假设。我们进一步假设，与额叶区相比，初级视觉皮层接受相对较少的DA神经支配，在MD受试者中显示正常的NAA/Cr比率。受试者包括9名MD男性（平均±标准差（sd））。= 32.5+/-6.4岁)和9名年龄匹配的对照男性(平均+/- sd。= 32.7 + / - -6.8年)。MD受试者4-13周不含ma。质子MRS代谢产物以肌酸比值表示；其绝对值不能区分对照组和MD受试者。在代谢物比率方面，MD男性的带带NAA/Cr显著降低(平均+/-标准误差（S.E.）：对照组= 1.46+/-0.03；Md = 1.30+/-0.03；Mann-Whitney P=0.01)，但在视觉皮层中没有(平均+/-S.E。:控制= 1.64 + / - -0.06;MD = 1.69 + / -11;Mann-Whitney P=0.52)。这些结果为NAA/Cr缺陷在MD受试者中是选择性的前扣带，至少在视觉皮层方面提供了证据。这些变化反映的神经元妥协可能有助于MD的注意力缺陷和抑制奖励系统。(C) 2002 Elsevier Science Ireland Ltd.。版权所有。
Studies based on animal models report that methamphetamine (MA) abuse diminishes dopamine (DA) and serotonin innervation in frontal brain regions. In this in vivo human study, we used proton magnetic resonance spectroscopy (MRS), which yields measures of N-acetyl-aspartate (NAA), a marker of living neurons, to examine frontal brain regions possibly affected by methamphetamine dependence (MD). We tested the hypothesis that MD subjects would exhibit abnormally low levels of NAA, referenced to creatine (Cr), in anterior cingulate gray matter. We further hypothesized that the primary visual cortex, which receives relatively less DA innervation than the frontal brain regions, would show normal NAA/Cr ratios in MD subjects. Subjects included nine MD men (mean+/-standard deviation (S.D.) = 32.5+/-6.4 years) and nine age-matched control men (mean+/-S.D. =32.7+/-6.8 years). The MD subjects were MA-free for 4-13 weeks. Proton MRS metabolites were expressed as ratios of creatine; the absolute values of which did not distinguish controls and MD subjects. With regard to metabolite ratios, the MD men had significantly lower NAA/Cr in the cingulum (mean+/-standard error (S.E.): control = 1.46+/-0.03; MD = 1.30+/-0.03; Mann-Whitney P=0.01) but not in the visual cortex (mean+/-S.E.: control=1.64+/-0.06; MD=1.69+/-11; Mann-Whitney P=0.52) relative to controls. These results provide evidence for NAA/Cr deficit that is selective to the anterior cingulum, at least with respect to visual cortex, in MD subjects. The neuronal compromise that these changes reflect may contribute to the attentional deficits and dampened reward system in MD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.