Maternal obesity, folate intake, and neural tube defects in offspring
Maternal obesity, folate intake, and neural tube defects in offspring
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DOI：
10.1002/bdra.23113
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发表时间：
2013-02-01
影响因子：
--
通讯作者：
Best, Robert G.
中科院分区：
文献类型：
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作者：
McMahon, Daria M.;Liu, Jihong;Best, Robert G.
背景我们调查了母亲肥胖(体重指数[BMI]30)与神经管缺陷影响妊娠(NTD)的风险之间的关系。我们还通过母亲BMI研究了围产期食物叶酸摄入量与NTD风险之间的关系。方法数据来自1992年至1997年在南卡罗来纳州进行的一项全州病例对照研究，包括179名患有NTD影响的孕妇和288名未受NTD影响的分娩的妇女。大多数病例母亲(77%)和对照组(86%)在分娩或终止妊娠后6个月内进行了访谈。使用Logistic回归模型，在调整了孕妇种族、年龄、教育程度、吸烟、酒精/药物使用、慢性病和在妊娠6个月内使用多种维生素后，检验了母亲肥胖与NTD风险之间的关系。按母亲BMI进行分层分析(25vs.
BACKGROUND We investigated the association between maternal obesity (body mass index [BMI] 30) and the risk of a neural tube defect affected pregnancy (NTD). We also studied relationships between perinatal folate intake from food and the NTD risk by maternal BMI. METHODS Data came from a state-wide case-control study conducted between 1992 and 1997 in South Carolina including 179 women with NTD-affected pregnancies and 288 women without NTD-affected births. A majority of case mothers (77%) and controls (86%) were interviewed within 6 months after delivery or pregnancy termination. Logistic regression models were used to examine the association between maternal obesity and the NTD risk after adjusting for maternal race, age, education, smoking, alcohol/drug use, chronic conditions, and multivitamin use within six periconceptional months. Stratified analysis by maternal BMI (25 vs.