Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
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DOI：
10.2337/diabetes.55.02.06.db05-0520
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发表时间：
2006-02-01
期刊：
影响因子：
7.7
通讯作者：
Jacobson, AM
中科院分区：
文献类型：
--
作者：
Musen, G;Lyoo, IK;Jacobson, AM
I型糖尿病和关键代谢变量对大脑结构的影响尚未得到很好的理解。评估大脑结构的敏感方法，如基于体素的形态测定法（VBM），以前没有被用于研究糖尿病人群的中枢神经系统变化。使用VBM，我们比较了年龄25-40岁、病程15-25年、糖尿病并发症最少的I型糖尿病患者与年龄匹配的非糖尿病对照组。我们研究了是否存在低于预期的灰质密度，如果是，它们是否与血糖控制和严重低血糖事件史相关。与对照组相比，糖尿病患者在几个脑区的灰质密度较低。此外，在患者组中，较高的HbA（1c）水平和严重的低血糖事件与负责语言处理和记忆的大脑区域的灰质密度较低有关。我们的研究代表了第一个全面研究1型糖尿病的灰质密度变化，并表明持续高血糖和急性严重低血糖对大脑结构有影响。
The effects of type I diabetes and key metabolic variables on brain structure are not well understood. Sensitive methods of assessing brain structure, such as voxel-based morphometry (VBM), have not previously been used to investigate central nervous system changes in a diabetic population. Using VBM, we compared type I diabetic patients aged 25-40 years with disease duration of 15-25 years and minimal diabetes complications with an age-matched, nondiabetic control group. We investigated whether lower than expected gray matter densities were present, and if so, whether they were associated with glycemic control and history of severe hypoglycemic events. In comparison with control subjects, diabetic patients showed lower density of gray matter in several brain regions. Moreover, in the patient group, higher HbA(1c) levels and severe hypoglycemic events were associated with lower density of gray matter in brain regions responsible for language processing and memory. Our study represents the first comprehensive study of gray matter density changes in type 1 diabetes and suggests that persistent hyperglycemia and acute severe hypoglycemia have an impact on brain structure.