Bioaccumulation and oxidative stress parameters in silver catfish (Rhamdia quelen) exposed to different thorium concentrations
Bioaccumulation and oxidative stress parameters in silver catfish (Rhamdia quelen) exposed to different thorium concentrations
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DOI：
10.1016/j.chemosphere.2009.07.022
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发表时间：
2009-10-01
期刊：
影响因子：
8.8
通讯作者：
Baldisserotto, Bernardo
中科院分区：
文献类型：
--
作者：
Kochhann, Daiani;Pavanato, Maria A.;Baldisserotto, Bernardo
本研究的目的是评估长期钍 (Th) 暴露对生物累积的影响。银鲶鱼（Rhamdia quelen）的新陈代谢（通过肌肉的生化参数）和氧化参数（鳃、肝和肌肉组织中的脂质过氧化水平和抗氧化酶）。将银鲶鱼幼鱼暴露于不同的水中Th水平（以μg L-1为单位）：0（对照）、25.3+/-3.2、80.6+/-12.0、242.4+/-35.6和747.2+/-59.1，持续30天。鳃和皮肤是积累Th水平最高的器官。水中 Th 浓度的增加与鳃和肾脏中 Th 水平的逐渐增加相对应。慢性 Th 暴露会导致银鲶鱼鳃的氧化参数发生变化，这与该器官中 Th 的积累相关。暴露于747.2μg L-1 Th的鱼鳃中GST水平下降，暴露于242.4和747.2μg L-1 Th的银鲶鱼的SOD活性下降。此外。暴露于242.4和747.2μg L-1 Th的鳃中LPO的增加表明鳃中发生了更高的氧化损伤。然而，在肝脏和肌肉中，这些改变主要发生在最低的水传播Th水平中。肌肉中的代谢中间体因钍暴露而改变，但没有发现明确的关系。 (C) 2009 Elsevier Ltd. 保留所有权利。
The objective of this study was to evaluate the effect of chronic thorium (Th) exposure on bioaccumulation. metabolism (through biochemical parameters of the muscle) and oxidative parameters (lipidic peroxidation levels and antioxidant enzymes in the gills and in the hepatic and muscular tissues) of silver catfish (Rhamdia quelen). Silver catfish juveniles were exposed to different waterborne Th levels (in mu g L-1): 0 (control), 25.3 +/- 3.2, 80.6 +/- 12.0, 242.4 +/- 35.6, and 747.2 +/- 59.1 for 30 d. The gills and skin were the organs that accumulated the highest Th levels. The increase in the waterborne Th concentration corresponded to a progressive increase in the Th levels in the gills and kidney. Chronic Th exposure causes alterations in the oxidative parameters of silver catfish gills, which are correlated with the Th accumulation in this organ. The levels of GST decreased in the gills of fish exposed to 747.2 mu g L-1 Th and SOD activity decreased in silver catfish exposed to 242.4 and 747.2 mu g L-1 Th. In addition. the increase in the LPO in the gills exposed to 242.4 and 747.2 mu g L-1 Th suggests that higher oxidative damage occurred in the gills. However, in the liver and muscle, these alterations occurred mainly in the lowest waterborne Th level. Metabolic intermediates in the muscle were altered by Th exposure, but no clear relationship was found. (C) 2009 Elsevier Ltd. All rights reserved.