Systemic Effects and Safety of Triamcinolone-Impregnated Nasal Packing after Endoscopic Sinus Surgery: A Randomized, Double-Blinded, Placebo-Controlled Study
Systemic Effects and Safety of Triamcinolone-Impregnated Nasal Packing after Endoscopic Sinus Surgery: A Randomized, Double-Blinded, Placebo-Controlled Study
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内窥镜鼻窦手术后曲安西龙浸渍鼻填塞的系统效应和安全性：一项随机、双盲、安慰剂对照研究
DOI：
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发表时间：
2013
影响因子：
2.6
通讯作者：
Jung Heob Sohn
中科院分区：
文献类型：
--
作者：
S. Hong;J. Kim;H. Dhong;H. Kim;Seung‐Kyu Chung;Young;Jung Heob Sohn
背景：鼻内镜手术（ESS）后使用类固醇灌注的可吸收鼻敷料可促进伤口愈合并减少息肉复发。然而，它们的系统影响并不为人所知。本研究的目的是评价激素浸渍的可吸收鼻腔填塞物后ESS的全身效应和安全性。方法将因慢性鼻窦炎接受双侧ESS的患者随机分为两组。曲安西龙（TA）组的10名患者在双侧鼻腔中接受了TA（20 mg）浸泡的生物可吸收敷料，而对照组的10名患者在双侧鼻腔中接受了盐水浸渍的敷料。直到术后第10天才移除鼻敷料。在术前和术后第2天和第10天测量血清皮质醇、12小时尿皮质醇、血清促肾上腺皮质激素（ACTH）和血清骨钙素。另外，在术后1天检查血清皮质醇水平，而在术后10天不检查尿皮质醇水平。结果20例患者全部完成研究。TA组术后第1天和第2天血清皮质醇水平明显降低。TA组术后2天血清ACTH和12小时尿皮质醇水平较低，但这些变化无统计学意义。术后第10天，TA组和对照组之间的所有其他参数均无差异。结论TA浸渍的鼻敷料在术后早期抑制血清皮质醇水平。术后10天，这种全身效应逐渐恢复正常。
Background Steroid-infused absorbable nasal dressings after endoscopic sinus surgery (ESS) have been used to improve wound healing and to reduce the recurrence of polyps. However, their systemic effects are not well known. The purpose of this study was to evaluate the systemic effects and safety of steroid-impregnated absorbable nasal packing after ESS. Methods Patients who underwent bilateral ESS for chronic rhinosinusitis were recruited and randomized into two groups. Ten patients in the triamcinolone (TA) group received a TA (20 mg)-soaked bioabsorbable dressing in both nasal cavities while 10 patients in the control group took saline-impregnated dressing in both nasal cavities. Nasal dressings were not removed until postoperative day 10. Serum cortisol, 12-hour urine cortisol, serum adrenal-corticotropic hormone (ACTH), and serum osteocalcin were measured preoperatively and on postoperative days 2 and 10. Serum cortisol levels were checked 1 day after surgery additionally, while urine cortisol levels were not checked at postoperative day 10. Results All 20 patients completed this study. The serum cortisol levels were significantly suppressed at postoperative days 1 and 2 in the TA group. Serum ACTH and 12-hour urine cortisol levels were lower 2 days after surgery in the TA group, although these changes were not statistically significant. There were no differences in all other parameters between the TA and control groups on postoperative day 10. Conclusions TA-impregnated nasal dressings suppress serum cortisol levels during the early postoperative period. This systemic effect was recovered gradually and normalized 10 days after the operation.
正常绝经前和绝经后妇女以及绝经后骨质疏松患者的血清骨钙素和全身钙。
DOI：
10.1210/jcem-64-4-681
发表时间：
1987
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Yasumura,S;Aloia,JF;Gundberg,CM;Yeh,J;Vaswani,AN;Yuen,K;LoMonte,AF;Ellis,KJ;Cohn,SH
通讯作者：
Cohn,SH
DOI：
10.1016/s0002-9343(97)00137-x
发表时间：
1997
期刊：
The American journal of medicine
影响因子：
--
作者：
Bikle,DD
通讯作者：
Bikle,DD