Proteases in invasion: matrix metalloproteinases
Proteases in invasion: matrix metalloproteinases
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DOI：
10.1006/scbi.2000.0365
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发表时间：
2001-04-01
影响因子：
14.5
通讯作者：
Yu, AE
中科院分区：
文献类型：
--
作者：
Stetler-Stevenson, WG;Yu, AE
蛋白酶，特别是基质金属蛋白酶在肿瘤侵袭和转移中的作用已得到充分证实。然而，这些酶仅仅提供了破坏结缔组织屏障的机制的经典观点受到了挑战。这篇综述总结了最近支持基质金属蛋白酶在癌症进展中作用的观点的证据。首先，我们简要回顾了细胞侵袭在癌症进展中的中心作用，以及基质金属蛋白酶家族成员。然后，我们专注于这些酶在癌症进展中的新兴作用，包括基质金属蛋白酶在细胞增殖和生长因子释放，细胞迁移和细胞外基质修饰中的作用，以揭示改变细胞行为的隐藏位点。
The role of proteases in general, and the matrix metalloproteinases in particular, in tumor invasion and metastasis is well established. However, the classic view that these enzymes simply provide a mechanism for the breakdown of connective tissue barriers has been challenged. This overview summarizes recent evidence to support the changing view of the role of matrix metalloproteinases in cancer progression. First we briefly review the central role of cell invasion in cancer progression and also the matrix metalloproteinase family members. We then focus on the emerging roles for these enzymes in cancer progression, including the role of matrix metalloproteinases in cell proliferation and release of growth factors, cell migration and in modification of the extracellular matrix to reveal cryptic sites that alter cell behaviour.