THE CHRONOTROPIC ACTION OF NEUROTENSIN IN THE GUINEA-PIG ISOLATED HEART
THE CHRONOTROPIC ACTION OF NEUROTENSIN IN THE GUINEA-PIG ISOLATED HEART
复制标题
DOI：
10.1016/0196-9781(85)90311-0
复制
发表时间：
1985-01-01
期刊：
影响因子：
3
通讯作者：
RIOUX, F
中科院分区：
文献类型：
--
作者：
BACHELARD, H;STPIERRE, S;RIOUX, F
将神经降压素（NT）注入豚鼠离体、灌流、自发搏动的心脏，引起浓度依赖性的正性变时效应，在某些心脏中，这种效应之前会出现短暂的心动过缓。普萘洛尔、西咪替丁、吲哚美辛、麦角新碱和吗啡的混合物或切除心房对NT引起的心动过速无影响。新斯的明可增加NT引起的心动过缓的发生率和幅度，而阿托品可降低其发生率和幅度。新斯的明和阿托品也分别有降低和升高NT引起的心动过速的趋势。提示NT对豚鼠离体心脏的正性变时作用是直接作用于心脏的特异性传导系统，而其负性变时作用可能是NT激活心脏迷走胆碱能神经元所致。
Neurotensin (NT) infusions into isolated, perfused, spontaneously beating hearts of guinea pigs evoked a concentration-dependent, positive chronotropic effect which was preceded in some hearts by transient bradycardia. The tachycardia caused by NT was not affected by propranolol, cimetidine, indomethacin, a mixture of methysergide and morphine or by atria removal. The incidence and amplitude of bradycardia caused by NT were increased by neostigmine but reduced by atropine. Neostigmine and atropine also tended to decrease and increase respectively, the tachycardia caused by NT. These results suggest that the positive chronotropic effect of NT in guinea pig isolated heart results from a direct effect on the specialized conduction system of the heart while its negative chronotropic effect is likely to reflect the activation by NT of cardiac vagal cholinergic neurons.