Cockroach allergen levels and associations with cockroach-specific IgE
Cockroach allergen levels and associations with cockroach-specific IgE
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DOI：
10.1016/j.jaci.2007.08.024
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发表时间：
2008-01-01
影响因子：
14.2
通讯作者：
Jacobson, Judith S.
中科院分区：
文献类型：
--
作者：
Chew, Ginger L.;Perzanowski, Matthew S.;Jacobson, Judith S.
背景资料：在内城儿童哮喘，蟑螂过敏原暴露已与过敏sensitivity.Objective：我们假设，在家中的蟑螂过敏原水平将与致敏蟑螂过敏原在children.Methods：从一个低收入的学前班计划，341名4岁的儿童选择的基础上，他们的照顾者参加这项研究。从他们的床上和厨房的灰尘进行了分析蟑螂（Bla g 2），小鼠（小鼠尿蛋白），猫过敏原（Fel d 1）。结果：儿童床尘和厨房尘中Bla g2水平> 1U/g与蟑螂特异性IgE独立相关（比值比[OR]，2.7; 95% CI，1.1-6.4;和OR，3.4; 95%CI，分别为1.2-9.4），调整性别，种族，哮喘，宠物所有权，母亲的过敏性致敏，环境烟草烟雾，并住在其他家庭。在哮喘儿童中，Bla g 2与蟑螂特异性IgE相关（OR，3.6; 95% CI，1.0-13.1）。在没有哮喘的儿童中，OR值相似（OR，3.0; 95%CI，0.9-10.3），但相关性不具有统计学意义。结论：浓度的主要蟑螂过敏原，Bla g 2，在沉降的灰尘与蟑螂特异性IgE独立于其他因素在一个队列的4岁的城市儿童。
Background: Among inner-city children with asthma, cockroach allergen exposure has been associated with allergic sensitization.Objective: We hypothesized that cockroach allergen levels in homes would be associated with sensitization to cockroach allergens in children.Methods: From a low-income preschool program, 341 four-year-old children selected on the basis of the willingness of their caregivers to participate in the study were enrolled. Dust from their beds and kitchens were analyzed for cockroach (Bla g 2), mouse (mouse urinary proteins), and cat allergens (Fel d 1). Serum samples were analyzed for allergen-specific IgE antibodies by immunoassay.Results: Bla g 2 levels > 1 U/g in children's bed and kitchen dust samples were independently associated with cockroach-specific IgE (odds ratio [OR], 2.7; 95% CI, 1.1-6.4; and OR, 3.4; 95% CI, 1.2-9.4, respectively), adjusting for sex, ethnicity, asthma, pet ownership, mother's allergic sensitization, environmental tobacco smoke, and having lived in other homes. Bla g 2 was associated (OR, 3.6; 95% CI, 1.0-13.1) with cockroach-specific IgE among children with asthma. Among children without asthma, the ORs were similar (OR, 3.0; 95% CI, 0.9-10.3), but the association was not statistically significant.Conclusion: Concentrations of the major cockroach allergen, Bla g 2, in settled dust were associated with cockroach-specific IgE independent of other factors in a cohort of 4-year-old inner-city children.