Triazole-linked analogue of deoxyribonucleic acid (TLDNA):: Design, synthesis, and double-strand formation with natural DNA
Triazole-linked analogue of deoxyribonucleic acid (TLDNA):: Design, synthesis, and double-strand formation with natural DNA
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DOI：
10.1021/ol801230k
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发表时间：
2008-09-04
期刊：
影响因子：
5.2
通讯作者：
Nakamura, Eiichi
中科院分区：
文献类型：
--
作者：
Isobe, Hiroyuki;Fujino, Tomoko;Nakamura, Eiichi
设计并合成了一种新的三唑连接的DNA类似物（（TL）DNA）。利用铜催化的Huisgen环加成反应成功地进行了链延长反应，得到了与天然DNA互补链形成稳定双链的人工寡核苷酸。
A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.