Cortical reorganization in children with cochlear implants
Cortical reorganization in children with cochlear implants
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DOI：
10.1016/j.brainres.2008.08.026
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发表时间：
2008-11-06
期刊：
影响因子：
2.9
通讯作者：
Dorman, Michael F.
中科院分区：
文献类型：
--
作者：
Gilley, Phillip M.;Sharma, Anu;Dorman, Michael F.
先天性耳聋导致听觉神经系统的非典型组织。然而，耳聋时听觉通路重组的程度还不清楚。我们记录了听力正常儿童和安装人工耳蜗的先天性耳聋儿童的皮层听觉诱发电位。高密度EEG和源建模显示听力正常和早期植入儿童的听觉皮层的主要活动。然而，在7年的关键期后植入的儿童显示了顶叶颞叶皮层对听觉刺激的反应，表现出重组的皮层通路。中枢听觉通路的重组受到植入发生年龄的限制，这可能有助于解释先天性耳聋儿童植入的益处和局限性。(C)2008 Elsevier B.V.保留所有权利。
Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children. (C) 2008 Elsevier B.V. All rights reserved.