THALASSEMIA - CONSEQUENCES OF UNBALANCED HEMOGLOBIN SYNTHESIS
THALASSEMIA - CONSEQUENCES OF UNBALANCED HEMOGLOBIN SYNTHESIS
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DOI：
10.1016/0002-9343(66)90039-8
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发表时间：
1966-01-01
影响因子：
5.9
通讯作者：
GUNN, RB
中科院分区：
文献类型：
--
作者：
NATHAN, DG;GUNN, RB
本文对地中海贫血中异质细胞的形态、红细胞动力学和代谢进行了综述。临床上明显的疾病在许多方面是由于血红蛋白的组成部分而不是没有组成的部分。严重地中海贫血是一种溶血性和亨氏体贫血，与红细胞代谢明显异常有关。治疗应针对纠正不平衡亚基产生引起的异常。
In this review the morphology, erythrokinetics and metabolism of the heterogeneous cells observed in thalassemia were discussed. The clinically overt disorder is in many respects due to the fraction of hemoglobin that is made rather than the fraction that is not made. Severe thalassemia is a hemolytic and Heinz body anemia associated with pronounced abnormalities ol red cell metabolism. Treatment should be directed to correction of the abnormalities induced by unbalanced subunit production.