Combined measurement of plasma cystatin C and low-density lipoprotein cholesterol: A valuable tool for evaluating progressive supranuclear palsy
Combined measurement of plasma cystatin C and low-density lipoprotein cholesterol: A valuable tool for evaluating progressive supranuclear palsy
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血浆胱抑素 C 和低密度脂蛋白胆固醇的联合测量：评估进行性核上性麻痹的宝贵工具
DOI：
10.1016/j.parkreldis.2018.03.014
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发表时间：
2018-07-01
影响因子：
4.1
通讯作者：
Gao, Xiaoya
中科院分区：
文献类型：
--
作者：
Weng, Ruihui;Wei, Xiaobo;Gao, Xiaoya
前言：进行性核上性麻痹（PSP）以前被认为是非典型帕金森综合征的一个原因。虽然半胱氨酸蛋白酶抑制剂C（Cys C）和低密度胆固醇脂蛋白-C（LDL-C）是已知的帕金森氏症中发挥关键作用，它是未知的，它们是否可以作为标志物来区分PSP患者从健康subjects.Methods的疾病严重程度：我们进行了一项横断面研究，以确定血浆Cys C/HDL/LDL-C水平的40例PSP和40名健康的年龄匹配的控制。采用运动和神经心理学测试，包括PSP评定量表（PSPRS）、非运动症状量表（NMSS）、老年抑郁量表（GDS）和简易精神状态检查量表（MMSE）评估疾病严重程度。结果：PSP患者血浆Cys C水平显著高于正常对照组，而LDL-C水平显著低于正常对照组，且与正常对照组比较差异有统计学意义（P < 0. 05）。血浆Cys C水平与PSPRS/NMSS评分呈正相关，与MMSE评分呈负相关。LDL-C/HDL-C比值与PSPRS/NMSS和GDS评分呈正相关。Cys C和LDL-C的组合的ROC曲线产生了更好的准确性区分PSP从健康subjects比单独的曲线为each parameter.Conclusions：血浆Cys C和LDL-C可能是有价值的筛选工具区分PSP从健康subjects;而他们可能是有用的PSP的强化和严重程度的评估。更好地了解Cys C和LDL-C可能有助于深入了解PSP的发病机制。(C)2018爱思唯尔有限公司版权所有
Introduction: Progressive supranuclear palsy (PSP) was previously thought as a cause of atypical Parkinsonism. Although Cystatin C (Cys C) and low-density cholesterol lipoprotein-C (LDL-C) are known to play critical roles in Parkinsonism, it is unknown whether they can be used as markers to distinguish PSP patients from healthy subjects and to determine disease severity.Methods: We conducted a cross-sectional study to determine plasma Cys C/HDL/LDL-C levels of 40 patients with PSP and 40 healthy age-matched controls. An extended battery of motor and neuropsychological tests, including the PSP-Rating Scale (PSPRS), the Non-Motor Symptoms Scale (NMSS), Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE), was used to evaluate the disease severity. Receiver operating characteristic (ROC) curves were adopted to assess the prognostic accuracy of Cys C/LDL-C levels in distinguishing PSP from healthy subjects.Results: Patients with PSP exhibited significantly higher plasma levels of Cys C and lower LDL-C. The levels of plasma Cys C were positively and inversely correlated with the PSPRS/NMSS and MMSE scores, respectively. The LDL-C/HDL-C ratio was positively associated with PSPRS/NMSS and GDS scores. The ROC curve for the combination of Cys C and LDL-C yielded a better accuracy for distinguishing PSP from healthy subjects than the separate curves for each parameter.Conclusions: Plasma Cys C and LDL-C may be valuable screening tools for differentiating PSP from healthy subjects; while they could be useful for the PSP intensifies and severity evaluation. A better understanding of Cys C and LDL-C may yield insights into the pathogenesis of PSP. (C) 2018 Elsevier Ltd. All rights reserved.