Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination.
Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination.
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DOI：
10.1002/glia.22977
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发表时间：
2016-06
期刊：
影响因子：
6.2
通讯作者：
Tapinos, Nikos
中科院分区：
文献类型：
--
作者：
Ness, Jennifer K.;Skiles, Amanda A.;Yap, Eng-Hui;Fajardo, Eduardo J.;Fiser, Andras;Tapinos, Nikos
Nuc‐ErbB3 an alternative transcript from the ErbB3 locus binds to a specific DNA motif and associates with Schwann cell chromatin. Here we generated a nuc‐ErbB3 knockin mouse that lacks nuc‐ErbB3 expression in the nucleus without affecting the neuregulin‐ErbB3 receptor signaling. Nuc‐ErbB3 knockin mice exhibit hypermyelination and aberrant myelination at the paranodal region. This phenotype is attributed to de‐repression of myelination associated gene transcription following loss of nuc‐ErbB3 and histone H3K27me3 promoter occupancy. Nuc‐ErbB3 knockin mice exhibit reduced association of H3K27me3 with myelination‐associated gene promoters and increased RNA Pol‐II rate of transcription of these genes. In addition, nuc‐ErbB3 directly regulates levels of H3K27me3 in Schwann cells. Nuc‐ErbB3 knockin mice exhibit significant decrease of histone H3K27me3 methyltransferase (HMT) activity and reduced levels of H3K27me3. Collectively, nuc‐ErbB3 is a master transcriptional repressor, which regulates HMT activity to establish a repressive chromatin landscape on promoters of genes during peripheral myelination. GLIA 2016;64:977–992 Nuc‐ErbB3 knock‐in mice exhibit peripheral hypermyelination. Nuc‐ErbB3 regulates total levels of H3K27me3 and HMT activity. Nuc‐ErbB3 induces transcriptional repression of myelination associated genes.
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影响因子：
5.3
作者：
Kuhlbrodt, K;Herbarth, B;Wegner, M
通讯作者：
Wegner, M
DOI：
10.1093/bioinformatics/bts565
发表时间：
2012-12-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Fu L;Niu B;Zhu Z;Wu S;Li W
通讯作者：
Li W
影响因子：
6.2
作者：
Heinen, Andre;Tzekova, Nevena;Kuery, Patrick
通讯作者：
Kuery, Patrick
影响因子：
5.3
作者：
Ma, Ki H.;Hung, Holly A.;Svaren, John
通讯作者：
Svaren, John
影响因子：
3.7
作者：
Adilakshmi T;Sudol I;Tapinos N
通讯作者：
Tapinos N