Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells
Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells
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DOI：
10.1016/j.fct.2012.12.009
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发表时间：
2013-03-01
影响因子：
4.3
通讯作者：
Aboussekhra, Abdelilah
中科院分区：
文献类型：
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作者：
Elamin, Maha H.;Daghestani, Maha H.;Aboussekhra, Abdelilah
乳腺癌是全世界妇女的一个主要健康问题。然而，其发病率因人口和地理位置而异。这些变化可能与饮食有关，因为现代饮食中有几种致癌化合物，而天然产品含有各种抗癌元素。一些证据表明，除了它们明确的预防作用之外，这些化合物还可以用作治疗剂。在本报告中，我们已经表明橄榄苦苷，一种安全的橄榄叶天然产物，具有有效的抗乳腺癌特性。事实上，橄榄苦苷表现出对乳腺癌细胞的特异性细胞毒性，对基底样MDA-MB-231细胞的作用高于对管腔MCF-7细胞的作用。这种作用是通过线粒体途径诱导细胞凋亡介导的。橄榄苦苷还可通过使细胞周期阻滞于S期和上调细胞周期蛋白依赖性抑制因子p21来抑制细胞增殖。此外，橄榄苦苷抑制抗凋亡和促增殖蛋白NE-κ B及其主要致癌靶点细胞周期蛋白D1。这种抑制作用可以解释橄榄苦苷对乳腺癌细胞增殖和细胞死亡的巨大影响。因此，橄榄苦苷需要进一步研究以证明其在预防/治疗乳腺癌，特别是反应性较低的基底样型乳腺癌中的效用。(C)2012爱思唯尔有限公司保留所有权利。
Breast cancer constitutes a major health problem for women worldwide. However, its incidence varies between populations and geographical locations. These variations could be diet-related, since there are several carcinogenic compounds in the modern diet, while natural products contain various anti-cancer elements. Several lines of evidence indicate that, in addition to their clear preventive effect, these compounds could also be used as therapeutic agents. In the present report we have shown that oleuropein, a pharmacologically safe natural product of olive leaf, has potent anti-breast cancer properties. Indeed, oleuropein exhibits specific cytotoxicity against breast cancer cells, with higher effect on the basal-like MDA-MB-231 cells than on the luminal MCF-7 cells. This effect is mediated through the induction of apoptosis via the mitochondrial pathway. Moreover, oleuropein inhibits cell proliferation by delaying the cell cycle at S phase and up-regulated the cyclin-dependent inhibitor p21. Furthermore, oleuropein inhibited the anti-apoptosis and pro-proliferation protein NE-kappa B and its main oncogenic target cyclin D1. This inhibition could explain the great effect of oleuropein on cell proliferation and cell death of breast cancer cells. Therefore, oleuropein warrants further investigations to prove its utility in preventing/treating breast cancer, especially the less-responsive basal-like type. (C) 2012 Elsevier Ltd. All rights reserved.