Femoral-gluteal adiposity is not associated with insulin sensitivity in type 1 diabetes.
Femoral-gluteal adiposity is not associated with insulin sensitivity in type 1 diabetes.
复制标题
股臀肌肥胖与 1 型糖尿病患者的胰岛素敏感性无关。
DOI：
10.1111/j.1464-5491.2012.03728.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Orchard,TJ
中科院分区：
文献类型：
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作者：
Shay,CM;Secrest,AM;Miller,RG;Strotmeyer,ES;Goodpaster,BH;Kelsey,SF;Orchard,TJ
AimsTo quantify and compare associations between femoral–gluteal adiposity and insulin sensitivity in adults with Type 1 diabetes mellitus with adults with normal glucose tolerance.MethodsIndividuals with Type 1 diabetes (n= 28) were recruited from the Pittsburgh Epidemiology of Diabetes Complication study, a 24‐year prospective study of childhood‐onset diabetes, and compared cross‐sectionally with individuals with normal glucose tolerance (n= 56) of similar age, sex and BMI. Insulin sensitivity was defined as whole‐body glucose disposal measured by hyperinsulinaemic–euglycaemic clamps. Adiposity was quantified by dual energy X‐ray absorptiometry.ResultsIndividuals with Type 1 diabetes exhibited lower insulin sensitivity (5.8 vs. 8.2 mg min−1kg fat‐free mass−1,P< 0.01), lower total fat mass (20.1 vs. 29.0 kg,P< 0.001) and lower proportional leg fat mass (36.0 vs.37.7%,P= 0.03), but similar proportional trunk fat (% trunk fat mass) compared with individuals with normal glucose tolerance. Overall, results from linear regression demonstrated that higher % leg fat mass (P< 0.01) and lower % trunk fat mass (P< 0.01) were independently associated with lower insulin sensitivity after adjustments for age, sex, height, total fat mass (kg) and diabetes status. Higher % leg fat mass was independently associated with higher insulin sensitivity in individuals with normal glucose tolerance (P< 0.01) after similar adjustment; significant associations were not observed in Type 1 diabetes.ConclusionsReduced insulin sensitivity is a prominent feature of Type 1 diabetes and is associated with total and abdominal adiposity. Compared with adults with normal glucose tolerance, leg fat mass does not show any positive association with insulin sensitivity in Type 1 diabetes.
