Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions.
Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions.
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DOI：
10.1053/j.ackd.2010.04.002
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发表时间：
2010-07-01
影响因子：
2.9
通讯作者：
Unruh, Mark L
中科院分区：
文献类型：
--
作者：
Soni, Ritu K;Porter, Anna C;Unruh, Mark L
随着高血压患病率的增加，人们越来越关注高血压患者的健康相关生活质量（HRQOL）。虽然高血压通常被认为是无症状的，但由于并发症或合并症、对诊断的认识以及抗高血压药物的不良反应，它与HRQOL受损相关。本文重点介绍了自2000年以来发表的文献，对老年高血压患者以及高血压合并疾病，包括慢性肾脏疾病，心血管疾病和糖尿病的HRQOL。大多数研究发现，高血压患者与共存的共病倾向于有较低的HRQOL比那些只有高血压，并确定共病的数量作为HRQOL的一个独立的决定因素。在HRQOL的身体功能领域中观察到最明显的效果。研究还检查了特定类别的降压药物对HRQOL的影响，但没有具体证明一种药物类别在HRQOL指标方面优于另一种药物。虽然有证据支持血管紧张素转换酶抑制剂可改善高血压患者的肾脏和心血管结局，但其在改善HRQOL结局方面的作用仍有待确定。
With the increasing prevalence of hypertension, there has been a growing interest in understanding the health-related quality of life (HRQOL) of patients with hypertension. Although hypertension is often perceived as asymptomatic, it is associated with impaired HRQOL because of complications or comorbidities, awareness of the diagnosis, and adverse effects from antihypertensive medications. This article focuses on the literature published since 2000, on HRQOL in elderly hypertensive individuals as well as hypertensives with co-existent diseases, including chronic kidney disease, cardiovascular disease, and diabetes mellitus. Most of the studies found that hypertensive individuals with co-existent co-morbidities tend to have lower HRQOL than those with hypertension alone, and identified the number of co-morbid illnesses as an independent determinant of HRQOL. The most pronounced effect was noted in the physical function domains of HRQOL. Studies have also examined the effects on HRQOL of specific classes of antihypertensive drugs without specific demonstration of superiority of one drug class over another in terms of HRQOL measures. Although there is evidence in favor of angiotensin-converting enzyme-inhibition for improving renal and cardiovascular outcomes in hypertensive patients, its role in ameliorating HRQOL outcomes remains to be established.