Factors influencing the formation of small dense low-density lipoprotein particles in dependence on the presence of the metabolic syndrome and on the degree of glucose intolerance
Factors influencing the formation of small dense low-density lipoprotein particles in dependence on the presence of the metabolic syndrome and on the degree of glucose intolerance
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DOI：
10.1111/j.1742-1241.2007.01507.x
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发表时间：
2007-11-01
影响因子：
2.6
通讯作者：
Pietzsch, J.
中科院分区：
文献类型：
--
作者：
Julius, U.;Dittrich, M.;Pietzsch, J.
背景：众所周知，小而密的低密度脂蛋白（LDL）颗粒特别容易导致动脉粥样硬化。这种动脉粥样硬化性涉及多种机制。目的：我们想要根据性别、代谢综合征 (MS) 和不同程度的葡萄糖不耐症来寻找小而密的 LDL 颗粒的存在。此外，我们还寻找与 LDL 大小变化相关的人体测量因素以及脂质和碳水化合物代谢因素。结果：我们研究了 752 人（330 名男性，422 名女性；年龄 40 +/- 17 岁）。 LDL 颗粒大小通过聚丙烯酰胺凝胶电泳估算。男性的低密度脂蛋白颗粒比女性更小。患有多发性硬化症的先证者的低密度脂蛋白颗粒比没有这种综合征的先证者要小。随着血浆甘油三酯 (TG) 水平的升高，可以看到更小的致密 LDL 颗粒。在 2 型糖尿病患者亚组中观察到这些小而密的 LDL 颗粒比例最高。在整个材料中，平均LDL直径与血浆TG和极低密度脂蛋白成分（TG、胆固醇和蛋白质）呈负相关，与高密度脂蛋白胆固醇呈正相关。在线性逐步回归分析中，在整个人群、血糖正常的先证者、糖耐量受损者、2 型糖尿病患者和注射胰岛素的 2 型糖尿病患者中发现了影响 LDL 大小的不同显着因素。结论：我们的数据表明，根据葡萄糖耐受不良的程度，小而致密的 LDL 颗粒形成的不同机制。此外，血浆TG的目标值应设置得较低。
Background: Small dense low-density lipoprotein (LDL) particles are known to be especially atherogenic. Several mechanisms are involved in this atherogenicity. Aims: We wanted to look for the presence of small dense LDL particles depending on gender, metabolic syndrome (MS) and different degrees of glucose intolerance. Moreover, we looked for anthropometric factors and factors of lipid and carbohydrate metabolism that are associated with changes in the LDL size. Results: We studied 752 persons (330 males, 422 females; age 40 +/- 17 years). LDL particle size was estimated with polyacrylamide gel electrophoresis. Males had smaller LDL particles than females. Probands with the MS had smaller LDL particles than those without this syndrome. With rising plasma triglyceride (TG) levels more small dense LDL particles were seen. The highest proportion of these small dense LDL particles was observed in the subgroup of type 2 diabetic patients. In the whole material, the mean LDL diameter was correlated negatively with plasma TG and very low-density lipoprotein components (TG, cholesterol and proteins) and positively with high-density lipoprotein cholesterol. In a linear stepwise regression analysis different significant factors influencing the LDL size were found in the whole population, in normoglycaemic probands, in persons with impaired glucose tolerance, in type 2 diabetic patients and in type 2 diabetic patients injecting insulin. Conclusions: Our data point to different mechanisms of the formation of small dense LDL particles in dependence on the degree of glucose intolerance. Moreover, the target values for plasma TG should be set lower.