Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infection
Estrogen increases menopausal host susceptibility to experimental ascending urinary-tract infection
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DOI：
10.1086/511275
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发表时间：
2007-03-01
影响因子：
6.4
通讯作者：
Nowicki, Stella
中科院分区：
文献类型：
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作者：
Curran, Edward M.;Hart-Van Tassell, Audrey;Nowicki, Stella
雌激素替代疗法对上行性尿路感染(UTI)的保护作用存在争议。我们设计了一项使用尿路感染实验模型的研究，在该模型中，手术绝经的小鼠补充雌激素，并在实验性大肠杆菌感染后评估对尿路感染的敏感性。未服用雌激素组的平均发病率为2×10(4)cfu/g肾组织，而雌激素组的平均感染率为9×10(8)cfu/g(P<；.001)。令人惊讶的是，尽管假设雌激素可以保护小鼠免受感染，但雌激素治疗显著增加了小鼠对尿路感染上升的易感性。
The protective effect of estrogen replacement on ascending urinary-tract infection ( UTI) is controversial. We designed a study using an experimental model of UTI in which surgically menopausal mice were supplemented with estrogen and the susceptibility to UTI was evaluated after experimental Escherichia coli infection. The mean rate of E. coli infection in the group not treated with estrogen was 2 x 10(4) cfu/g of renal tissue, compared with 9 x 10(8) cfu/g (P < .001)) in the estrogen-treated group. Surprisingly, despite the hypothesis that estrogen would protect mice from infection, estrogen treatment significantly increased the susceptibility of the mice to ascending UTI.