Diarrhea caused by rotavirus in children less than 5 years of age in Hanoi, Vietnam
Diarrhea caused by rotavirus in children less than 5 years of age in Hanoi, Vietnam
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DOI：
10.1128/jcm.42.12.5745-5750.2004
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发表时间：
2004-12-01
影响因子：
9.4
通讯作者：
Weintraub, A
中科院分区：
文献类型：
--
作者：
Nguyen, TV;Le Van, P;Weintraub, A
A组轮状病毒是全球幼儿腹泻的主要原因。2001年3月至2002年4月，在越南河内对836名5岁以下儿童进行了调查。其中包括587名腹泻儿童和249名年龄匹配的对照组。A组轮状病毒在腹泻患儿中的检出率为46.7%，对照组为3.6%，差异有统计学意义。在腹泻组中，13至24个月的儿童患病率最高，男性患病率高于女性。轮状病毒引起的急性腹泻症状为水样腹泻、呕吐、发热和脱水。轮状病毒的检出率较高的儿童谁拥有所有这些症状，其次是那些谁有腹泻呕吐脱水，发烧脱水，脱水。尽管全年都有感染，但9月至12月的发病率较高。在58例轮状病毒感染儿童中，检出轮状病毒感染与致肠源性大肠埃希菌或志贺氏菌相关。最常见的组合是轮状病毒-肠聚集性E。大肠杆菌和轮状病毒肠致病性E.杆菌从大约64%的样本中至少鉴定出一种肠道病原体。细菌感染可能不会引起如此严重的临床症状。目前的研究表明轮状病毒腹泻的负担在河内，越南。对轮状病毒引起的幼儿腹泻的持续监测将在诊断、治疗和预防方面发挥重要作用，以改善越南儿童的健康状况。
Group A rotaviruses are the major cause of diarrhea in young children worldwide. From March 2001 to April 2002, 836 children less than 5 years of age were investigated in Hanoi, Vietnam. This included 587 children with diarrhea and 249 age-matched controls. Group A rotavirus was identified in 46.7% of the children with diarrhea and 3.6% of the controls, which was a significant difference. Within the diarrhea group, the highest prevalence was seen in children from 13 to 24 months of age, and the prevalence was higher in males than in females. The symptoms of acute diarrhea caused by rotavirus were watery diarrhea, vomiting, fever, and dehydration. A higher prevalence of rotavirus detection was obtained for children who had all of these symptoms, followed by those who had diarrhea with vomiting-dehydration, fever-dehydration, and dehydration. The high rates occurred from September to December, although the infection was encountered all year round. In 58 patients (21.2% of the rotavirus-infected children), rotavirus infection was detected in association with either diarrheagenic Escherichia coli or Shigella spp. The most frequent combinations were rotavirus-enteroaggregative E. coli and rotavirus-enteropathogenic E. coli. At least one enteropathogen was identified from about 64% percent of the samples. The bacterial infection may not have given rise to clinical symptoms of such severity. The present study demonstrates the burden of rotavirus diarrhea in Hanoi, Vietnam. Continuous surveillance of diarrhea caused by rotavirus in young children would play an important role in diagnosis, treatment, and prophylaxis in order to improve the health of children in Vietnam.