IMPAIRMENT OF ENDOTHELIUM-DEPENDENT ARTERIAL RELAXATION BY LYSOLECITHIN IN MODIFIED LOW-DENSITY LIPOPROTEINS
IMPAIRMENT OF ENDOTHELIUM-DEPENDENT ARTERIAL RELAXATION BY LYSOLECITHIN IN MODIFIED LOW-DENSITY LIPOPROTEINS
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DOI：
10.1038/344160a0
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发表时间：
1990-03-08
期刊：
影响因子：
64.8
通讯作者：
HENRY, PD
中科院分区：
文献类型：
--
作者：
KUGIYAMA, K;KERNS, SA;HENRY, PD
动物和人类的动脉粥样硬化与动脉和小动脉对内皮依赖性血管扩张剂1 -3的无反应性有关--内皮依赖性血管扩张剂通过刺激血管扩张剂成分（内皮源性舒张因子）从内皮细胞释放而间接作用于平滑肌4。动脉粥样硬化中血管调节的改变可能部分反映了异常脂蛋白对内皮的损伤作用5，6。最近，“细胞修饰的”或“氧化的”低密度脂蛋白（EC-LDL）由于其潜在的细胞毒性和致动脉粥样硬化特性而受到越来越多的关注7。我们在此报告，暴露于EC-LDLin的动脉显示出与动脉粥样硬化动脉非常相似的内皮依赖性血管调节障碍。我们的研究结果表明，从EC-LDL到内皮细胞膜的溶血素转移产生了选择性的受体调节的内皮依赖性血管舒张剂的无反应性。
ATHEROSCLEROSIS in animals and humans is associated with an unresponsiveness of arteries and arterioles to endothelium-dependent vasodilators1–3—agents acting on smooth muscle indirectly by stimulating the release from endothelial cells of a vasodilator principle (endothelium-derived relaxing factor)4. Altered vasomotor regulation in atherosclerosis could partly reflect an injurious action of abnormal lipoproteins on endothelium5,6. Recently, 'cell-modified' or 'oxidized' low-density lipoprotein (EC-LDL) has received increasing attention because of its potential cytotoxic and atherogenic properties7. We report here that arteries exposed to EC-LDLin vitroshow an endothelium-dependent vasoregulatory impairment closely resembling that of atherosclerotic arteries. Our results indicate that transfer of lysolecithin from EC-LDL to endothelial membranes produces a selective unresponsiveness to receptor-regulated endothelium-dependent vasodilators.