SEQUENTIAL MONITORING OF CLINICAL-TRIALS - THE ROLE OF INFORMATION AND BROWNIAN-MOTION
SEQUENTIAL MONITORING OF CLINICAL-TRIALS - THE ROLE OF INFORMATION AND BROWNIAN-MOTION
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DOI：
10.1002/sim.4780120804
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发表时间：
1993-04-30
影响因子：
2
通讯作者：
ZUCKER, DM
中科院分区：
文献类型：
--
作者：
LAN, KKG;ZUCKER, DM
在过去的二十年中，序贯监测一直是临床试验方法学中备受关注的一个主题。本文提出了一个用于序贯监测的统一概念框架，该框架涵盖了各种临床试验环境中的多种监测程序。这个框架的核心要素包括一个合适的统计信息概念，以及一个方案，该方案将此概念用作以标准化形式总结试验累积结果的基础，通过一个可证明近似于经典布朗运动的随机过程来实现。这些想法以一种简单的逐步方式展开，并通过几个实际例子进行了说明。
Sequential monitoring has been a topic of major interest in clincal trials methodology over the past two decades. This paper presents a unified conceptual framework for sequential monitoring that covers a wide variety of monitoring procedures in a wide variety of clinical trial settings. The central elements of this framework consist of a suitable concept of statistical information and a scheme for using this concept as a basis for summarizing the accumulating results of a trial in a standardized form, through a stochastic process that can be shown to approximate classical Brownian motion. The ideas are developed in a simple step-by-step fashion and illustrated by several practical examples.