Variability in step training enhances locomotor recovery after a spinal cord injury.
Variability in step training enhances locomotor recovery after a spinal cord injury.
复制标题
DOI：
10.1111/j.1460-9568.2012.08106.x
复制
发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Edgerton VR
中科院分区：
文献类型：
--
作者：
Shah PK;Gerasimenko Y;Shyu A;Lavrov I;Zhong H;Roy RR;Edgerton VR
运动任务的表现通过练习具有对训练方案增加的“挑战”的特定任务来改善。我们测试的假设，即在没有大脑控制的情况下，运动任务的表现是通过使用该任务的特定变化的训练来增强的。本研究采用改良的台阶训练方法，以提高脊髓损伤大鼠的前向台阶能力。20只成年大鼠在胸段脊髓全横断后，随机分为3组，每组10只，分别在跑步机上进行前、侧、后3种方向的踏步，共28次（20 min，5d/周），然后检测其前向踏步能力。尽管所有训练组的动物均表现出改善，但与前向训练组的大鼠相比，侧向训练组和后向训练组的大鼠具有更大的步伐一致性和协调性沿着，以及在前向步进期间每步来自所选后肢肌肉的整流肌电图信号的更高的峰值幅度和总积分活动。我们的研究结果表明，通过保留电机任务（双足步进）的基本特征，执行该电机任务的能力可以通过添加特定的上下文变化的任务（步进方向）来增强。我们的数据表明，向前步进神经元运动网络的部分补充同步激活的interneuronal/运动神经元的人口，也是一部分的侧向或向后步进运动网络。因此，神经元元素的重叠和相互作用可能在积极的任务转移中起着关键作用。
Performance of a motor task is improved by practicing a specific task with added “challenges” to a training regimen. We tested the hypothesis that in the absence of brain control the performance of a motor task is enhanced by training using specific variations of that task. We utilized modifications of step performance training to improve the ability of spinal rats to forward step. After a complete thoracic spinal cord transection, 20 adult rats were divided randomly to bipedally step on a treadmill in the forward, sideward, or backward direction for 28 sessions (20 min, 5d/week) and subsequently tested for their ability to step in the forward direction. Although the animals from all trained groups showed improvement, the rats in the sideward trained and backward trained groups had greater step consistency and coordination along with higher peak amplitudes and total integrated activity of the rectified electromyography signals from selected hindlimb muscles per step during forward stepping than the rats in the forward trained group. Our results demonstrate that by retaining the fundamental features of a motor task (bipedal stepping) the ability to perform that motor task can be enhanced by the addition of specific contextual variations to the task (direction of stepping). Our data suggest that the forward stepping neuronal locomotor networks are partially complemented by synchronous activation of interneuronal/motoneuronal populations that are also a part of the sideward or backward stepping locomotor networks. Accordingly, the overlap and interaction of neuronal elements may play a critical role in positive task transference.