Event-related potentials and cue-reactivity in alcoholism
Event-related potentials and cue-reactivity in alcoholism
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DOI：
10.1111/j.1530-0277.2000.tb01974.x
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发表时间：
2000-11-01
影响因子：
3.2
通讯作者：
Fallgatter, AJ
中科院分区：
文献类型：
--
作者：
Herrmann, MJ;Weijers, HG;Fallgatter, AJ
背景：复吸是成瘾行为治疗中的一个主要问题。酒精成瘾的条件反射模型表明，与以前的药物使用（线索）相关的刺激可能会在一组特定的酗酒者中引发复发。事件相关电位（ERPs）可能是有用的，以揭示大脑功能基板的线索reactivity.Methods：在初步调查中，11酒精依赖患者谁没有参加的电生理研究完成了结构化面试率80个字的程度与酒精。在此基础上，对19名酒精依赖者进行了15个酒精相关词和15个无关词的线索反应性研究（44.2 +/- 8.5岁）和19名健康对照男性（42.5 +/- 12.5岁）。在酒精依赖患者中，与无关词相比，与酒精相关词后的ERPs的幅度显著更高，而对照组则无此现象[F（1，36）= 5.2，p < 0.05]。结论：与假设一致的是，只有酒精依赖患者的特征是与酒精相关的脑活动增加。因此，研究结果支持基于神经生物学测量的酒精中毒线索反应性的概念。未来的研究将显示这种线索反应性是否可以应用于评估个体酒精依赖患者复发的风险。
Background: Relapse is a major problem in the treatment of addictive behaviors. Conditioning models of alcohol addiction suggest that stimuli associated with previous drug use (cues) may initiate relapse in a definite group of alcoholics. Event-related potentials (ERPs) might be useful to reveal the brain functional substrates of cue-reactivity.Methods: In a preliminary investigation, 11 alcohol-dependent patients who did not take part in the electrophysiological study completed a structured interview to rate 80 words as to the degree of relatedness to alcohol. Based on these results, cue-reactivity for 15 alcohol-related and 15 unrelated word cues, each repeated eight times, was investigated in 19 alcohol-dependent men (44.2 +/- 8.5 years) and 19 healthy control men (42.5 +/- 12.5 years).Results: A cue-reactivity that consisted of significantly higher amplitudes in the ERPs after alcohol-related words compared with unrelated words was found in alcohol-dependent patients, but not in controls, at the electrode location Pz [F(1,36) = 5.2,p < 0.05].Conclusions: Consistent with the hypothesis, only alcohol-dependent patients were characterized by signs of increased cerebral activity associated with alcohol-related compared with unrelated cues. Therefore, the results support the concept of cue-reactivity in alcoholism based on a neurobiological measurement. Future investigations will show whether this cue-reactivity can be applied to assess the risk of relapse in individual alcohol-dependent patients.