THE TIME COURSE OF THE IMMUNE-RESPONSE TO EXPERIMENTAL CORONAVIRUS INFECTION OF MAN
THE TIME COURSE OF THE IMMUNE-RESPONSE TO EXPERIMENTAL CORONAVIRUS INFECTION OF MAN
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DOI：
10.1017/s0950268800048019
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发表时间：
1990-10-01
影响因子：
4.2
通讯作者：
TYRRELL, DAJ
中科院分区：
文献类型：
--
作者：
CALLOW, KA;PARRY, HF;TYRRELL, DAJ
经过初步试验，在 15 名接种冠状病毒 229E 的志愿者中追踪了特异性循环抗体和局部抗体浓度的详细变化。其中 10 名先前存在的抗体浓度明显低于测试结果的人被感染，其中 8 名患上了感冒。对循环淋巴细胞群的有限调查显示，受感染的志愿者出现了一些淋巴细胞减少症。在该组中，抗体浓度在 1 周后开始增加。此后抗体滴度缓慢下降。尽管一年后浓度仍略有上升，但这并不能总能防止当志愿者接受同源病毒攻击时的再次感染。不过，病毒排出的时间比以前短了，没有人患上感冒。所有未感染组在再次攻击时都被感染，尽管它们似乎也表现出对疾病和感染程度的一定抵抗力。这些结果是参考冠状病毒和其他感染（例如鼻病毒感染）的自然感染进行讨论的。
After preliminary trials, the detailed changes in the concentration of specific circulating and local antibodies were followed in 15 volunteers inoculated with coronavirus 229E. Ten of them, who had significantly lower concentrations of preexisting antibody than the test, became infected and eight of these developed colds. A limited investigation of circulating lymphocyte populations showed some lymphocytopenia in infected volunteers. In this group, antibody concentrations started to increase 1 week later. Thereafter antibody titres slowly declined. Although concentrations were still slightly raised 1 year later, this did not always prevent reinfection when volunteers were then challenged with the homologous virus. However, the period of virus shedding was shorter than before and none developed a cold. All of the uninfected group were infected on re-challenge although they also appeared to show some resistance to disease and in the extent of infection. These results are discussed with reference to natural infections with coronavirus and with other infections, such as rhinovirus infections.