The metabolism of D- and L-pipecolic acid in the rabbit and rat.
The metabolism of D- and L-pipecolic acid in the rabbit and rat.
复制标题
D-和L-哌可酸在兔和大鼠中的代谢。
DOI：
10.1016/0304-4165(81)90034-9
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Hutzler,J
中科院分区：
文献类型：
--
作者：
Dancis,J;Hutzler,J
The metabolism ofD- andL-pipecolic acid has been investigated in rabbits and rats. A rapid evolution of14CO2followed the injection of eitherD- orL-pipe[6-14C]colic acid into rabbits. Rabbit kidney slices degraded to CO2both isomers of lysine and of pipecolic acid. Rabbit liver was effective with only theL-isomers. In the rat, very little of injectedL-pipecolic acid was catabolized to CO2, and large amounts were excreted unchanged into the urine.L-Lysine was efficiently metabolized to CO2by rat liver and kidney slices but notD-lysine or either isomer of pipecolic acid. Rat kidney convertedD-lysine toL-pipecolic acid. TheL-isomer was identified by co-precipitation of the radioactive product with authentic compounds.
