A new implant with solid core and porous surface: The biocompatability with bone
A new implant with solid core and porous surface: The biocompatability with bone
复制标题
具有实心核心和多孔表面的新型植入物：与骨的生物相容性
DOI：
10.1002/jbm.a.34906
复制
发表时间：
2014
影响因子：
4.9
通讯作者：
Zhou Yi
中科院分区：
文献类型：
--
作者：
Yang Xu;Wang Dihua;Liang Youde;Yin Huayi;Zhang Shuang;Jiang Tao;Wang Yining;Zhou Yi
本研究探讨了具有过渡性多孔-固体结构的Farthing-Fray-Chen钛种植体的成骨能力。对材料特性、生物力学性能、成骨性能进行评价。FFcTi的表面粗糙度与喷砂和酸蚀处理的纯钛(SA)相似，但亲水性高于SA和机械加工的工业纯钛(MA)。在压缩试验中，FFcTi种植体的杨氏模数为15.8 ± 6.3 Gpa，接近骨质。体外观察表明，MC3T3-E1细胞在FFcTi和SA上具有良好的铺展能力。细胞在MA、SA和FFcTi4h的黏附率逐渐降低(MA >； SA，p <； 0.0 1；SA >； FFcTi，p <； 0.0 5)，1~6d细胞在FFcTi上的增殖能力弱于MA(p <； 0.0 1)，第11天与MA和SA相似。第14天，FFcTi上细胞的碱性磷酸酶活力高于MA，低于SA(p <； 0.0 1)。在兔骨缺损模型中，在50μm范围内，FFcTiBIC和骨体积比显著高于MA(BIC，p <； 0.0 1；BT0.0 5，p <； 0.0 5)，而骨体积比在10 0和5 0 0μm范围内无差异。Micro CT分析也显示了与组织形态计量学数据相似的结果。因此，我们认为熔融球状多孔结构的FFcTi具有亲水性，表面粗糙，与骨的弹性系数接近。在体外，其低增殖率和促进碱性磷酸酶活性的作用与其他微尺度粗糙表面相似。体内实验显示，至少在2周内，与MA相比具有更好的成骨能力。因此，这种Farthing-Fray-Chen钛植入物似乎具有相当大的骨植入应用潜力。2013Wiley期刊，Inc.生物材料资源A部分：102A：2395-2407,2014。
This research investigated osteogenic potencies of Farthing–Fray–Chen Titanium (FFcTi) implant with transitional porous‐solid structure. The material characteristics, biomechanical property, osteogenic performances were assessed. FFcTi showed similar roughness as sand‐blasted and acid etched titanium (SA), but was more hydrophilic than SA and machined commercial pure titanium (MA). Young's modulus of FFcTi implant in compressive tests was 15.8 ± 6.3 GPa, which was close to bone. In vitro observations manifested excellent spreading abilities of MC3T3‐E1 cell on FFcTi and SA. Adhesion rates of MC3T3‐E1 cells at 4 h gradually decreased on MA, SA, and FFcTi surfaces (MA > SA, p < 0.01; SA > FFcTi, p < 0.05), while cell proliferation ability on FFcTi was weaker than MA during 1–6 days (p < 0.01) and similar to MA and SA in day 11. ALP activity of cells on FFcTi at 14 day was higher than MA and lower than SA (p < 0.01). In a bone defect model of rabbits, BIC and bone volum ratio within 50 μm were significantly higher for FFcTi than MA (BIC, p < 0.01; BT0.05, p < 0.05) while bone volume ratio within 100 and 500 μm were of no differences. Micro CT analysis also showed similar results to the histomorphometric data. Thus, we conclude that FFcTi with melting sphere based multiporous structure has a hydrophilic, rough surface, and close modulus to bone. In vitro, its low proliferation and ALP activity promotion were similar to other micro scale roughed surface. In vivo test showed better osteogenesis ability when compared with MA at least in 2 weeks. Thus, this Farthing–Fray–Chen Titanium implant seems to hold considerable potential for bone implant applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2395–2407, 2014.